Project description
The role of glycans and cell receptors in infections
Unveiling the roles of glycosylation and cell receptors in infection mechanisms and cancer is crucial for early detection, estimation of prognosis, and monitoring treatment response. With the support of the Marie Skłodowska-Curie Actions programme, the SPIRAL project will understand how critical protein receptors recognise and interact with glycans at the molecular level. The project will utilise Nuclear Magnetic Resonance (NMR) and other biophysical techniques to investigate the binding preferences of the recognition event between GD3 ganglioside and the spike proteins of OC43 and HKU1 human coronavirus (HCoV) variants. It will also address the role of Siglec-7 in inhibiting HCoV viral infection, providing valuable insights into the roles of glycosylation patterns and cell receptors in HCoV infection mechanisms.
Objective
The present project focuses on deeply comprehending the molecular basis of glycan recognition events by key protein receptors at atomic level, directly connected to processes related to immune response, infection and cancer. We will elucidate using Nuclear Magnetic Resonance (NMR) and other biophysical techniques the binding preferences of the recognition event between GD3 ganglioside and the Spike proteins of OC43 and HKU1 human coronavirus (HCoV) variants, along with Siglec-7. The role of Siglec-7 in inhibiting the HCoV viral infection will also be addressed. This research will make a significant and direct contribution by unveiling the roles of glycosylation patterns and cell receptors in HCoV infection mechanisms.
Dr. Bermejo, the applicant, defended her PhD Thesis almost five years ago and was awarded a MSCA-IF fellowship for the past three years. During this time she has grown into an excellent researcher in chemical biology, possessing practical experience in organic and peptide synthesis, drug design, lipid nanoparticles formulation, cell culture and binding assays. Through the awarding of this fellowship she will join the lab of Prof. Jesus Jimnez-Barbero the Scientific Director of the host institution (CIC bioGUNE) and Leader of the Chemical Glycobiology lab. He is one of the best-known scientists in glycan research at the national and international levels.
Thanks to this action, Dr. Bermejo will consolidate her multidisciplinary scientific proficiency, acquiring new competences in enzymatic synthesis and protein expression and purification and trend setting NMR concepts and techniques. She will contribute to the host with her expertise in glycan and glycoconjugates synthesis, and will bring her expertise in liposomal formulation, setting up a microfluidics device within the group.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences physical sciences classical mechanics fluid mechanics microfluidics
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences health sciences infectious diseases RNA viruses coronaviruses
- natural sciences biological sciences biochemistry biomolecules carbohydrates
- medical and health sciences clinical medicine oncology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2023-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
48160 DERIO VIZCAYA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.