Project description
Smart bioreactor-based platform for osteochondral tissue engineering research and applications
Functional regeneration of osteochondral tissue following injury or disease remains a critical unmet clinical need. Tissue engineering (TE) has emerged as a promising therapeutic strategy. However, the biophysical environment of the native osteochondral tissue is complex and difficult to replicate, limiting current TE strategies. With the support of the Marie Skłodowska-Curie Actions programme, SYNERGIES project will combine cutting-edge bioengineering methods and tools like biomaterials, bioreactors, in silico modelling and machine learning to develop a pioneer smart bioreactor-based platform. The platform will be used for culturing osteochondral tissue-engineered constructs under controlled physiologically and clinically relevant multi-physical stimulation conditions. SYNERGIES platform will enable an unseen knowledge gain in osteochondral tissue mechanobiology, fostering the development of new therapies and reliable in vitro models for osteochondral research and drug screening.
Objective
The incidence and socioeconomic burden of osteochondral (OC) diseases are growing worldwide, representing a major challenge for the healthcare systems. Tissue Engineering (TE) emerged as a promising alternative to the current ineffective OC disease treatments. However, state-of-the-art OCTE strategies are still unable to create functional engineered tissues, mainly due to their inability to replicate in vitro the complex physicochemical environment of the native OC tissue within the articular joint, making OC regeneration a critical unmet medical need.
The ambitious purpose of the SYNERGIES project is to fill this gap by developing a pioneering smart biomimetic bioreactor-based platform able to culture OC constructs under physiologically and clinically relevant multi-physical stimulations in a controlled and adaptive manner. Cutting-edge in silico modelling and machine learning (ML) tools will be employed for the operational parameters optimization and for the smart automated control of the bioreactor platform, respectively. The SYNERGIES platform will enhance the knowledge of OC tissue mechanobiology beyond the state-of-the-art and guide the improvement of protocols for the production of functional OC substitutes, which will be suitable in vitro models for OC disease research and drug screening, paving the way for new effective therapies.
The proposed Fellowship will enable a highly interdisciplinary collaboration between myself, a talented post-doc with a strong track record on biomaterial scaffolds for OCTE, and the supervisors, leading experts on bioreactor engineering and in silico modelling/ML tools. The excellent working conditions at Politecnico di Torino and 7HC will promote my professional development, offering me new scientific expertise and leadership skills, significantly widening my career perspectives. Ultimately, SYNERGIES outcomes will be of remarkable benefit to the European biomedical sector, contributing to EU excellence and quality of life.
Fields of science (EuroSciVoc)
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CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2023-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
10129 Torino
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.