Project description
Precision oncology in advanced breast cancers
Precision oncology is a cutting-edge approach to cancer treatment that tailors therapies based on the genetic profile of a patient's tumour. By matching specific genomic alterations with targeted drugs, it aims to enhance treatment efficacy and minimise side effects. Funded by the Marie Skłodowska-Curie Actions programme, the HD-BRECA project aims to enhance precision oncology and the ability to predict the treatment outcome of advanced breast cancers. The research team will integrate multi-dimensional data including genomic profiles, e-health records, medical imaging, and multi-omics to map disease trajectories and improve models for prognosis. This approach will move the focus from genomics-centred precision oncology to high-definition oncology, integrating longitudinal patient monitoring to achieve thorough personalised cancer care.
Objective
Precision Oncology has revolutionized cancer therapeutics, mostly by matching genomic alterations with molecularly targeted agents. Yet, current predictive capacity is imperfect even in best-case scenarios (tumors driven by oncogene addiction against which a targeted agent exists). To push the field forward, we propose to exploit recent technological advances to analyze longitudinal profiles of cancer patients that encompass dimensions beyond the genetic profile: physiological monitoring, e-health records, patient-reported outcomes, medical imaging, and multi-omics. The integration of this multi-dimensional data with personalized genomics will allow an unprecedented level of understanding of cancer processes, identifying the features that drive patient disease trajectories, eliciting truly precision interventions.
The goal of this project is to use this approach to improve the current predictive ability and break current efficacy plateaus in advanced breast cancers. I will integrate longitudinal data of a cohort of 100 hormone receptor-positive metastatic breast cancer patients in first line of treatment with CDK4/6 inhibitors and hormone inhibitors, monitored until disease progression or treatment failure. This constitutes the largest high-definition medicine study in advanced breast cancer patients to date. I will use data across 10 different modalities to establish disease trajectories, relate molecular features to clinical outcomes and build predictive models for prognosis.
This integrative project combines translational and clinical oncology, engineering, and data science, to transition from the current genomics-centered precision oncology approach to high-definition oncology, a model in which deep longitudinal patient monitoring achieves a comprehensive personalized oncology.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences health care services eHealth
- natural sciences biological sciences genetics
- medical and health sciences clinical medicine oncology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2023-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
28029 Madrid
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.