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ProINK4D: Engineering Dynamic Protein Hydrogels for 4D Bioprinting of Advanced Tissue Constructs

Project description

Innovative approach for advanced tissue engineering

Advancements in technology and 4D bioprinting enable new approaches in tissue engineering and regenerative medicine. With the support of the Marie Skłodowska-Curie Actions programme, the ProINK4D project will develop advanced protein-engineered biomaterials for 4D bioprinting of dynamic tissue constructs. The project draws inspiration from intrinsically disordered protein polymers (IDPPs) that exhibit lower and upper critical solution temperature (LCST and UCST) phase behaviours. It will create hybrid hydrogels by combining protein polymers with opposite thermoresponsive properties, leading to the development of preprogrammed, shape-morphing protein hydrogels. The comprehensive research plan covers bioproduction, material characterisation, bioink and bioresin optimisation, and advanced 4D bioprinting. The project will significantly impact scientific understanding and practical applications in tissue engineering and regenerative medicine.

Objective

The ProINK4D project embarks on a transformative journey to pioneer the development of next-generation protein-engineered biomaterials for 4D bioprinting of dynamic tissue constructs. Inspired by the intrinsic versatility of intrinsically disordered protein polymers (IDPPs) with lower and upper critical solution temperature (LCST and UCST) phase behaviors, this project aims to create hybrid hydrogels by ingeniously combining protein polymers exhibiting opposite thermoresponse properties. This innovative design strategy sets the stage for the creation of preprogrammed, shape-morphing protein hydrogels, paving the way for the development of responsive protein hydrogel actuators with enhanced efficiency. With a comprehensive research plan spanning bioproduction, material characterization, bioink and bioresin optimization, and advanced 4D bioprinting, ProINK4D promises to make a significant impact on both scientific understanding and practical applications in the realms of tissue engineering and regenerative medicine. Moreover, the project emphasizes rigorous project management, research innovation, and effective science communication to ensure the highest scientific quality and societal relevance of the generated knowledge and technology.

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Programme(s)

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Topic(s)

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Funding Scheme

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HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships

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Call for proposal

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(opens in new window) HORIZON-MSCA-2023-PF-01

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Coordinator

UNIVERSIDAD DE VALLADOLID
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 181 152,96
Address
PLAZA SANTA CRUZ 8 PALACIO DE SANTA CRUZ
47002 VALLADOLID
Spain

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Region
Centro (ES) Castilla y León Valladolid
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

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