Objective
The problem: Lack of water-equivalent dosimeters for radiotherapy
Cancer is a global public health problem. Radiotherapy is generally used as an essential method of cancer treatment. Measuring the absorbed dose of radiation to ensure that the radiation delivered to the patient is accurate, is paramount and critical to patient safety, since tumor control and side-effects are highly sensitive to the applied dose. For this purpose, in-vivo dosimetry (IVD) can be performed as a patient-specific measure of quality control and safety during radiotherapy. Clinical experience and dose prescriptions in radiotherapy have historically been based on the absorbed dose to water. However, when a calibrated dosimeter as for today, which is not water equivalent, is used under non-reference conditions, direct determination of the correct absorbed dose to water is not possible and many detectors show an over-response. Water equivalent dosimeters are not available but particularly desirable in clinical applications.
The solution: A small, water-equivalent, non-toxic and liquid dosimeter with electron paramagnetic resonance spectroscopy readout
This idea presents an innovative strategy for dose determination using a novel type of liquid, water-equivalent and non-toxic dosimeter with readout via electron paramagnetic resonance (EPR) spectroscopy. This novel liquid EPR dosimeter consists of a small (mm-dimensions) capsuled water-based liquid detector material that can be placed on the patient's skin or in body cavities to measure the delivered dose at relevant locations in clinical situations. The principle presented here is based on a dose-dependent EPR signal loss: Stable paramagnetic species dissolved in aqueous solution are transformed into diamagnetic products upon irradiation. The proposed solution is not an incremental improvement of an existing procedure but an innovative approach making IVD easier to use, cheaper, more accurate and: water equivalent.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine oncology
- natural sciences physical sciences optics spectroscopy
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC-POC - HORIZON ERC Proof of Concept Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2023-POC
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
78464 Konstanz
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.