Skip to main content
Vai all'homepage della Commissione europea (si apre in una nuova finestra)
italiano it
CORDIS - Risultati della ricerca dell’UE
CORDIS

Liquid Dosimetry via Electron Paramagnetic Resonance Spectroscopy

Obiettivo

The problem: Lack of water-equivalent dosimeters for radiotherapy

Cancer is a global public health problem. Radiotherapy is generally used as an essential method of cancer treatment. Measuring the absorbed dose of radiation to ensure that the radiation delivered to the patient is accurate, is paramount and critical to patient safety, since tumor control and side-effects are highly sensitive to the applied dose. For this purpose, in-vivo dosimetry (IVD) can be performed as a patient-specific measure of quality control and safety during radiotherapy. Clinical experience and dose prescriptions in radiotherapy have historically been based on the absorbed dose to water. However, when a calibrated dosimeter as for today, which is not water equivalent, is used under non-reference conditions, direct determination of the correct absorbed dose to water is not possible and many detectors show an over-response. Water equivalent dosimeters are not available but particularly desirable in clinical applications.

The solution: A small, water-equivalent, non-toxic and liquid dosimeter with electron paramagnetic resonance spectroscopy readout

This idea presents an innovative strategy for dose determination using a novel type of liquid, water-equivalent and non-toxic dosimeter with readout via electron paramagnetic resonance (EPR) spectroscopy. This novel liquid EPR dosimeter consists of a small (mm-dimensions) capsuled water-based liquid detector material that can be placed on the patient's skin or in body cavities to measure the delivered dose at relevant locations in clinical situations. The principle presented here is based on a dose-dependent EPR signal loss: Stable paramagnetic species dissolved in aqueous solution are transformed into diamagnetic products upon irradiation. The proposed solution is not an incremental improvement of an existing procedure but an innovative approach making IVD easier to use, cheaper, more accurate and: water equivalent.

Campo scientifico (EuroSciVoc)

Programma(i)

Argomento(i)

Meccanismo di finanziamento

HORIZON-ERC-POC - HORIZON ERC Proof of Concept Grants

Vedi tutti i progetti finanziati nell’ambito di questo schema di finanziamento

Invito a presentare proposte

(si apre in una nuova finestra) ERC-2023-POC

Vedi tutti i progetti finanziati nell’ambito del bando

Istituzione ospitante

UNIVERSITAT KONSTANZ
Contributo netto dell'UE
€ 150 000,00
Indirizzo
UNIVERSITATSSTRASSE 10
78464 Konstanz
Germania
Regione
Baden-Württemberg Freiburg Konstanz
Tipo di attività
Higher or Secondary Education Establishments
Collegamenti
Costo totale
Nessun dato

Beneficiari (1)