Project description
Digitalised biomanufacturing for next-generation therapies
Production of biopharmaceuticals and advanced therapies such as mRNA vaccines and gene therapies depends on complex manufacturing processes. These are increasingly difficult to optimise without digital tools. Digitalisation provides the potential to improve efficiency, reduce costs, and ensure quality control. The aim of the EU-funded DIG4BIO project is to advance the digitalisation of biomanufacturing processes through a strategic alliance between research institutions in Denmark, Germany, and Portugal. A particular focus is placed on the bacterial production of plasmid DNA, a key raw material for gene and cell therapies. Through joint research, training, and knowledge exchange, the project will build institutional capacity in digital biotechnology and contribute to next-generation biomanufacturing.
Objective
Digitalization of biDigitalisation of biomanufacturing is key to increasing efficiency, reducing costs, and ensuring quality control in the production of biopharmaceuticals and advanced therapies. Dig4Bio aims to: i) advance the research capacity and profile of the coordinator IST (PT) in the field of digitalisation of biomanufacturing, and ii) strengthen the research management and administrative skills of IST. This will be achieved through a strategic alliance with experts in digital biotechnology from PROSYS, DTU (Chemical and Biochemical Engineering, DK) and lab automation TU Berlin (Chair of Bioprocess Engineering DE). Dig4Bio includes 6 Work Packages (WPs). WP1 (Advancing scientific capacity) and WP2 (Enhancing research management capacity) focus on stepping up the scientific and research management skills of IST through tailored training (workshops, training schools, digital tools, short term visits). In WP3 (Joint research activities), Dig4Bio partners will collaborate on a pioneering R&I initiative that addresses the question: How to develop and incorporate a digitalisation framework in the conceptual design, research and development of biomanufacturing processes. Attention is focused on Escherichia coli-based manufacturing of plasmid DNA, a biomolecule that is gaining increased relevance as a biological (e.g. DNA vaccination, in vivo gene therapy), and as a raw material in the manufacturing of gene/cell therapies (e.g. mRNA vaccines). WP4 (Clustering Activities) aims to foster close ties, synergies and knowledge exchange between the consortium and stakeholders, whereas WP5 (Communication and Dissemination) aims to disseminate findings and promote awareness of the field. WP6 (Coordination and Management) provides the necessary administrative support to ensure the successful and timely execution of all project components. The expected outcomes for Dig4Bio include the elevation of IST profile in digitalisation of biomanufacturing and in research management.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences biochemistry biomolecules
- engineering and technology mechanical engineering mechatronics automation
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.4.1 - Widening participation and spreading excellence
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-CSA - HORIZON Coordination and Support Actions
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-WIDERA-2023-ACCESS-02
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1049 001 Lisboa
Portugal
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.