Project description
Gout prevention nutrition
Gout, a growing lifestyle-related disease in Europe, significantly reduces quality of life, and treatments are often ineffective. Managing hyperuricemia, the precursor to gout, could dramatically improve health outcomes. The EIC-funded Bugs4Urate project aims to address this issue by developing a new probiotic food ingredient with urate-lowering properties, targeting the gut microbiome within a precision nutrition framework. This framework will consider contextual factors including habitual diet, host gut microbiome and host genetics. The project will use machine learning, refine dietary fibre and probiotics and conduct two human intervention studies. Through comprehensive longitudinal analyses, Bugs4Urate seeks to develop an effective tool for identifying responders and non-responders, ultimately aiming to reduce serum urate levels, control inflammation, and prevent gout.
Objective
Gout is a prevalent lifestyle related NCD on the rise in Europe causing low quality of life, yet with inefficient means for treatment. An effective approach to manage hyperuricemia, the precursor to gout, would significantly enhance health outcomes and have a profound impact.
Using a novel probiotic food-ingredient with urate-lowering properties we target the gut microbiome to eradicate urate in a precision nutrition framework where contextualizing factors of the habitual diet, host gut microbiome, and host genetics is used to establish a responder / non-responder instrument.
We will employ a diverse array of methods, encompassing machine learning applied to existing clinical and omics observational data, ex-vivo dietary fiber and probiotic refinement, and two human intervention studies. In healthy adults (n = 8) we will conduct a mode-of-action study utilizing a crossover design including small intestine biopsy sampling to assess local activity. In hyperuricemic participants (n = 99) we will conduct a three-armed, placebo-controlled proof-of-concept study to access the efficacy of probiotic treatment (with and without fibre), combined with a responder / non-responder instrument.
Using comprehensive longitudinal analyses in metabolomics, microbiome, transcriptomics, and glycomics, we aim to uncover the molecular dynamics between dietary patterns, established bacterial enzymatic processes, urate breakdown, and the resultant shifts in inflammation within the gut and throughout the circulatory system. By innovating the glycomics technology to accommodate alternative bio-specimens, we hope to enable straightforward home sampling and initiate early diagnostic procedures for broad population oversight. Through the application of multi-omics, we aim to develop an effective responder / non-responder instrument to probiotic intervention for serum urate reduction, inflammation control, and gout prevention.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology materials engineering fibers
- medical and health sciences health sciences nutrition
- natural sciences biological sciences biochemistry biomolecules carbohydrates
- natural sciences biological sciences microbiology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.3.1 - The European Innovation Council (EIC)
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-EIC-2023-PATHFINDERCHALLENGES-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1165 KOBENHAVN
Denmark
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