Development of nutritional vesicles for precision diagnostics and therapeutics for metabolic diseases

Información del proyecto

NutriEV

Identificador del acuerdo de subvención: 101161353

DOI

10.3030/101161353

Fecha de la firma de la CE 3 Junio 2024

Fecha de inicio 1 Septiembre 2024

Fecha de finalización 31 Agosto 2028

Financiado con arreglo a

• The European Innovation Council (EIC)

Coste total

€ 3 943 243,75

Aportación de la UE

€ 3 943 243,75

Coordinado por

OULUN YLIOPISTO
Finland

Periodic Reporting for period 1 - NutriEV (Development of nutritional vesicles for precision diagnostics and therapeutics for metabolic diseases)

Período documentado: 2024-09-01 hasta 2025-08-31

Resumen del contexto y de los objetivos generales del proyecto

The NutriEV project is a pioneering initiative aimed at transforming our understanding of nutrition through the study of food-derived extracellular vesicles (nutriEVs). It investigates how EVs from raw and fermented foods act as nutritional components, biosensors, and potential superfoods, focusing on their biomolecular makeup—especially glycans—and their ability to deliver nutritional cargo to cells. The project advances precision nutrition by developing non-invasive technologies like sweat-based biosensors to monitor health impacts, using nutriEVs as biomarkers to enable personalized dietary recommendations linked to metabolic health, obesity, and gut inflammation. The project also explores the complex interactions between diet, the gut microbiome, and host metabolism, assessing how nutriEVs influence gut health, immune responses, and systemic metabolism through various study models. To support this goal, the project develops biochemical tools such as antibodies and labeling systems, along with advanced organoid and animal models to track and manipulate nutriEVs. Clinical studies are conducted to evaluate nutriEVs in humans, particularly in relation to obesity and dietary interventions, with the goal of translating findings into innovative food products, diagnostics, and therapies. Finally, NutriEV fosters interdisciplinary collaboration and actively disseminates its results to scientific, clinical, and public audiences, while also strategizing for the commercialization of its outcomes. In essence, NutriEV seeks to revolutionize nutrition science by unlocking the therapeutic and diagnostic potential of food-derived EVs.

Trabajo realizado desde el comienzo del proyecto hasta el final del período abarcado por el informe y los principales resultados hasta la fecha

Preparation of nutritional vesicles from cloudberries and investigation of their effects in mice after oral administration. Manuscript published in 2025: Cloudberry-derived nanovesicles as stable oral drug delivery systems: gastrointestinal stability and age-related biodistribution in mice by Shanthi et al. in the journal Nanoscale describes the effect of gastrointestinal environment on cloudberry-derived vesicles. https://pubs.rsc.org/en/content/articlelanding/2025/nr/d4nr04694c

Avances que van más allá del estado de la técnica e impacto potencial esperado (incluida la repercusión socioeconómica y las implicaciones sociales más amplias del proyecto hasta la fecha)

At this time we are investigating the acquisition and characterization of plant-derived nanovesicles. We will investigate the effect of the vesicles on human health in planned clinical trials. We exect to find significant results by the end of this project.