Project description
Nutrition influence on obese people’s immune responses
Obesity is associated with non-communicable diseases (NCDs) and increased infection risks. However, the exact impact of nutrition on immune responses is not fully understood. The EIC-funded NUTRIMMUNE project aims to explore how dietary factors influence immune responses in individuals with varying degrees of obesity-related NCD severity. The project will assess the relationship between nutrition, the glycome, the microbiome, and immune health in the context of obesity and immune impairment. A key focus is a 24-week precision nutritional intervention designed to evaluate the potential of a pro-immune diet in restoring T cell health in obese individuals. NUTRIMMUNE will identify predictive markers and signatures of altered immunity and dietary patterns that affect immune function. Additionally, the project ensures efficient management, ethics compliance and the dissemination and exploitation of its findings.
Objective
NUTRIMMUNE examines how dietary factors affect immune responses across varying degrees of obesity-related Noncommunicable Disease (NCD) severity. This focus is crucial given obesitys link to NCDs and infection risks. The project gathers 6 academic groups and 1 SME across 4 European countries over 4 years and a 4.3M grant to evaluate the interplay between nutrition, glycome, microbiome, and immune health in obesity and immune impairment.
NUTRIMMUNE leverages partners: i) Access to European databases and biobanks, enabling in-depth analysis at cellular and molecular levels, ii) Proficiency in conducting dietary intervention studies in human subjects, and iii) Experience in mechanistic and functional diet-glycome-microbiome interactions.
In WP1, the project deciphers phenotypic, multi-omics, and dietary factors responsible for variability in Immune Checkpoint (ICP) expression and immune impairment in existing cohorts. WP2 focuses on a 24-week precision nutritional intervention to assess the potential of a pro-immune diet to restore T cell fitness in obese subjects. WP3 conducts comprehensive profiling before and after the dietary intervention, examining innate and adaptive responses, cytokine patterns, alongside ICP labeling. WP4 provides mechanistic aspects on how the diet, glycome, microbiome influence immune health. WP5 employs machine learning models to identify predictive markers and signatures for ICP expression and altered immunity, to identify dietary patterns and food affecting immune function. WP6 ensures efficient project management and effective coordination, ethics compliance, dissemination, and exploitation. WP7 explores synergies with portfolio projects for challenge goals.
The projects goal is to move from our novel idea that precision nutrition influences immunity via microbiome and glycome, and present validated proof-of-concept evidence for nutritional recommendations and future food development.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
- natural sciencescomputer and information sciencesdatabases
- natural sciencesbiological sciencesmicrobiology
- medical and health scienceshealth sciencesnutritionobesity
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Programme(s)
- HORIZON.3.1 - The European Innovation Council (EIC) Main Programme
Topic(s)
Funding Scheme
HORIZON-EIC - HORIZON EIC GrantsCoordinator
75006 Paris
France