Project description
Nutrition influence on obese people’s immune responses
Obesity is associated with non-communicable diseases (NCDs) and increased infection risks. However, the exact impact of nutrition on immune responses is not fully understood. The EIC-funded NUTRIMMUNE project aims to explore how dietary factors influence immune responses in individuals with varying degrees of obesity-related NCD severity. The project will assess the relationship between nutrition, the glycome, the microbiome, and immune health in the context of obesity and immune impairment. A key focus is a 24-week precision nutritional intervention designed to evaluate the potential of a pro-immune diet in restoring T cell health in obese individuals. NUTRIMMUNE will identify predictive markers and signatures of altered immunity and dietary patterns that affect immune function. Additionally, the project ensures efficient management, ethics compliance and the dissemination and exploitation of its findings.
Objective
NUTRIMMUNE examines how dietary factors affect immune responses across varying degrees of obesity-related Noncommunicable Disease (NCD) severity. This focus is crucial given obesitys link to NCDs and infection risks. The project gathers 6 academic groups and 1 SME across 4 European countries over 4 years and a 4.3M grant to evaluate the interplay between nutrition, glycome, microbiome, and immune health in obesity and immune impairment.
NUTRIMMUNE leverages partners: i) Access to European databases and biobanks, enabling in-depth analysis at cellular and molecular levels, ii) Proficiency in conducting dietary intervention studies in human subjects, and iii) Experience in mechanistic and functional diet-glycome-microbiome interactions.
In WP1, the project deciphers phenotypic, multi-omics, and dietary factors responsible for variability in Immune Checkpoint (ICP) expression and immune impairment in existing cohorts. WP2 focuses on a 24-week precision nutritional intervention to assess the potential of a pro-immune diet to restore T cell fitness in obese subjects. WP3 conducts comprehensive profiling before and after the dietary intervention, examining innate and adaptive responses, cytokine patterns, alongside ICP labeling. WP4 provides mechanistic aspects on how the diet, glycome, microbiome influence immune health. WP5 employs machine learning models to identify predictive markers and signatures for ICP expression and altered immunity, to identify dietary patterns and food affecting immune function. WP6 ensures efficient project management and effective coordination, ethics compliance, dissemination, and exploitation. WP7 explores synergies with portfolio projects for challenge goals.
The projects goal is to move from our novel idea that precision nutrition influences immunity via microbiome and glycome, and present validated proof-of-concept evidence for nutritional recommendations and future food development.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences computer and information sciences databases
- natural sciences biological sciences microbiology
- medical and health sciences health sciences nutrition obesity
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.3.1 - The European Innovation Council (EIC)
MAIN PROGRAMME
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-EIC - HORIZON EIC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-EIC-2023-PATHFINDERCHALLENGES-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75006 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.