Project description
Sustainable technologies for the pharmaceutical industry
The healthcare sector contributes 3-8 % of CO2 emissions in OECD countries and consumes vast resources. PharmEco, supported by the EU and private partners of the Innovative Health Initiative, aims to transform the pharmaceutical industry by adopting more sustainable manufacturing practices. The project will explore innovative technologies and processes in chemical synthesis, biomanufacturing and decontamination to reduce the use of solvents, substances of very high concern, energy and water. It will scale-up SSbD-driven technologies, optimise manufacturing processes and develop digital decision-support for sustainability steering. Additionally, PharmEco will establish harmonised guidelines for environmental impact evaluation, providing a comprehensive toolkit for sustainable pharmaceutical production and life cycle assessment, ultimately fostering a greener and more responsible healthcare sector.
Objective
PHARMECO is supported by the Innovative Health Initiative Joint Undertaking (IHI JU). The JU receives support from the European Union’s Horizon Europe research and innovation programme and COCIR, EFPIA, Europa Bío, MedTech Europe, and Vaccines Europe.
The project's overall objective is to revolutionize pharmaceutical manufacturing towards sustainability by integrating environmentally friendly technologies/processes and harmonized sustainability assessments methods into healthcare industry practices. This encompasses early design phase, operation, and eventual use and disposal. The project's first objective is to enhance the early-stage development of pharmaceutical products by implementing Sustainable-by-Design (SSbD)-driven process-intensified platforms (e.g. continuous manufacturing). This involves designing sustainable processes based on so-called SELECT (Safety, Environment, Legal, Economy, Control and Throughput) criteria and setting up eco-friendly systems for producing small molecules, peptides, oligo-nucleotides, proteins and ribonucleic acid (RNA) with advanced control measures. Next, PHARMECO aims to scale up and demonstrate environmentally-friendly processes for industrial manufacturing and decontamination, which includes creating infrastructure for studying key unit operations with sustainable technology and for SSbD-driven process intensified manufacture at a scale sufficient for clinical testing and a manufacturing process that is easily transferred to a Good Manufacturing Practice (GMP) environment. PHARMECO also aims to steer the development of (bio)manufacturing processes towards sustainable production through digital decision-making tools. This involves creating a modular digital tool for assessing sustainability from multiple perspectives, evaluating practices. Finally, the project seeks to establish a standardized approach for assessing the environmental sustainability of pharmaceuticals, which involves collaboration with various stakeholders to create scientifically robust guidelines, applying consistent Life Cycle Assessment (LCA) methodologies, and facilitate regulatory adoption of standardized LCA practices.
By integrating sustainability considerations into every phase of manufacturing, PHARMECO will positively revolutionize pharmaceutical industry.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteins
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines
- natural sciencesbiological sciencesgeneticsRNA
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Keywords
- Route design
- Decontamination
- Pilot and scale up
- Cradle-to-grave
- LCA
- Harmonized standards
- Pharmaceutical Manufacturing
- Continuous manufacturing
- Process intensification
- digital twin
- PAT
- SSbD
- sustainability
- Biomanufacturing
- chemical synthesis
- drug substance
- Green Chemistry
- New Biological Entity
- New chemical Entity
- sterilization
- supercritical CO2
- API
- active pharmaceutical ingredient
Programme(s)
- HORIZON.2.1 - Health Main Programme
- HORIZON.2.1.7 - Innovative Health Initiative
Call for proposal
(opens in new window) HORIZON-JU-IHI-2023-04-two-stage
See other projects for this callFunding Scheme
HORIZON-JU-RIA - HORIZON JU Research and Innovation ActionsCoordinator
9000 Gent
Belgium
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Participants (27)
8010 Graz
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8010 Graz
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501 15 Boras
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10623 Berlin
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46980 Paterna
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6525 XZ Nijmegen
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2800 MECHELEN
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20014 DONOSTIA - SAN SEBASTIAN
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8412 Allerheiligen Bei Wildon
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3721 MA Bilthoven
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451 76 UDDEVALLA
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69003 Lyon
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54600 VILLERS-LES-NANCY
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891 22 Ornskoldsvik
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60064 North Chicago Il
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CB2 0AA Cambridge
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55218 Ingelheim
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2340 Beerse
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01600 Trevoux
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2880 Bagsvaerd
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64293 Darmstadt
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10001-2192 NEW YORK CITY
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65929 Frankfurt Am Main
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91190 GIF-SUR-YVETTE
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9000 GENT
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WC1A 1DG LONDON
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1070 Bruxelles / Brussel
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Partners (26)
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
TS10 4RF Redcar Cleveland
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DH8 6TJ Consett
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LE11 3TU Loughborough
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DE 19850 Wilmington
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55218 Ingelheim
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64293 Darmstadt
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64293 Darmstadt
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1267 Coinsins
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64293 Darmstadt
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00176 Roma
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10010 Colleretto Giacosa
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CT13 9NJ Sandwich
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CT13 9NJ Sandwich
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T12 Cork
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94250 Gentilly
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0214 Cambridge, Massachusetts
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02142 Cambridge
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94250 Gentilly
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4822NH BREDA
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40789 Monheim
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SL1 3WE Slough
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1630 Bulle
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76210 Bolbec
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65205 Wiesbaden
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600113 TamilNadu
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