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METABOLIC REGULATION OF GENOME FUNCTION AND CELL IDENTITY

Project description

Exploring how metabolism influences disease

Emerging evidence indicates that metabolic processes influence the function of the genome and the identity of cells including stem cell differentiation and reprogramming. Metabolic intermediates can modulate the activity of transcription factors and chromatin modifiers, influencing gene expression and chromatin dynamics. Insight from this field of research can help unveil mechanisms underlying diseases like cancer and open avenues for the development of novel therapeutics. With the support of the Marie Skłodowska-Curie Actions programme, the NUCLEAR project combines expertise from all over Europe to train doctoral candidates in nuclear metabolism and cancer therapies, setting the foundation for enhancing Europe’s research visibility.

Objective

NUCLEAR aims at educating future experts that can drive the emerging field of Metabolic Regulation of Genome Function and Cell Identity relevant for stem cell biology and cancer. It is a Doctoral Training Network composed of 14 beneficiaries and 12 partner organisations including three industrial partners, a training-oriented foundation, a patient support association from 8 EU member states, 1 associated country and a non-EU member state self-funding itself to the level of beneficiary. Given the highly interdisciplinary nature of this emerging field, no single institution can provide all suitable infrastructures and the know-how required for high-quality PhD-level training. To address this shortfall in training capacity, NUCLEAR brings together European leaders in metabolomics, functional genomics, chromatin regulation, stem cell biology and cancer with innovators in precision nutrition, mass spectrometry technologies and drug development. Together we are committed to the following:
1. To train 16 doctoral candidates (DCs) through an innovative program structured in four capacity axes and occurring on three complementary levels to deliver enabling scientific and transferable skills.
2. To guide DCs in collaborative research bridging boundaries of countries, sectors, and disciplines.
3. To address three key challenges that limit the advancement and exploitation of the field and that are the lack of tools to measure nuclear metabolism, the lack of understanding of underlying molecular mechanisms and the lack of targets for novel cancer therapies.
4. To build lasting infrastructures for dissemination, communication and exploitation promoting an entrepreneurial culture and maximizing and extending the impact of this proposal beyond its lifetime.
5. To increase the international visibility of European research by taking leadership in the emerging field of Metabolic Regulation of Genome Functions and Cell Identity.

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Programme(s)

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Topic(s)

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Funding Scheme

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HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral Networks

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Call for proposal

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(opens in new window) HORIZON-MSCA-2023-DN-01

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Coordinator

FUNDACIO INSTITUT DE RECERCA CONTRA LA LEUCEMIA JOSEP CARRERAS
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 503 942,40
Address
CARRETERA DE CAN RUTI CAMI DE LES ESCOLES S/N
08916 Badalona
Spain

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Links
Total cost

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Participants (14)

Partners (14)

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