Project description
Innovative targets against multidrug-resistant Staphylococcus aureus
Multidrug-resistant Staphylococcus aureus (MRSA) infections constitute a significant medical issue due to their resistance to commonly used antibiotics. Invasive S. aureus can cause infections with a range of clinical manifestations, including pneumonia, endocarditis and sepsis. They are difficult to treat and often require the combination of antibiotics. With the support of the Marie Skłodowska-Curie Actions programme, the AUREUS project aims to train the next scientific workforce to combat MRSA infections. The project aims to develop immune-based therapies by exploring the biosynthesis and structure of S. aureus cell wall glycopolymers and understand how the human immune system responds to them. Project findings are expected to advance future drug discovery efforts to counteract infections caused by MRSA and related bacterial species.
Objective
The AUREUS doctoral network meets the increasing need of a highly qualified work force to counteract multidrug-resistant S. aureus infections by performing cutting-edge, inter-disciplinary research in the multifaceted field of chemical biology.
The proposed research program aims at training Doctoral Candidates (DCs) to acquire complementary skills to exploit and develop different and innovative strategies to i) unveil the biosynthesis and structure of unique S. aureus cell wall glycopolymers, the so-called WTA (wall teichoic acids), ii) gain greater insights into the molecular basis of the human immune responses to S. aureus WTA, iii) harness the acquired knowledge to rationally design and develop effective immune-based therapies against S. aureus and related bacterial species.
To this end, the AUREUS intersectoral program is based on a unique international team combining expertise in different fields including chemistry, (micro-)biology and immunology. In detail, 9 world academic leaders in the glycoscience and/or S. aureus research world and 4 companies (SMEs) with world-class expertise in glycoscience, cutting-edge diagnostics and therapeutic research programs will be involved in the AUREUS project. Each DC will have their own individual project, based on fundamental science and with practical applications, either in biotechnology or in biomedicine, as will be explored through secondments with our industrial partners.
The AUREUS network will provide 14 young scientists with broad, top-class scientific and professional competences and skills, thereby expanding the pipeline of future leaders for both industry and academia.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine immunology
- natural sciences biological sciences microbiology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral Networks
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2023-DN-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
80138 Napoli
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.