Project description
Immune cell tracking during immunotherapy
Cancer immunotherapy can help the immune system recognise and attack cancer cells. Treatments include monoclonal antibodies, cytokines, adoptive immune cell transfer or other immune-modulating approaches. Despite their promise, the mechanisms behind these therapies remain poorly understood, particularly how immune cells relocate and interact post-treatment. With the support of the Marie Skłodowska-Curie Actions programme, the T-RAFIC project aims to increase knowledge of immune cell trafficking during therapy, especially during immunotherapy combinations. The consortium will employ technological advancements to enable unprecedented tracking of immune cells and ultimately contribute to improve treatment efficacy in this emerging field in oncology and beyond.
Objective
Cancer immunotherapies have been established in a growing number of clinical indications and the pace of development is massively accelerating. Currently over 6.000 clinical trials are investigating immune-related treatments in oncology especially in combinations. It includes both adoptive cellular therapies and immune modulating treatments like immune check point blockade. In contrast, the understanding of how such therapies mediate their mode of action is still mostly poorly understood. In particular, the role of distribution and relocation of immune cells after therapeutic interventions remains unknown. This is surprising, as immune cell interactions are a hallmark of therapeutic immune responses. T-RAFIC will enhance understanding of immune cell trafficking under therapeutic influence. It will open new paths and avenues to treatments, boost their efficacy and help prioritizing the plethora of immune therapeutic combinations. In the past, detailed analysis of cellular distributions was facing technical barriers. Advances in technologies, now permit tracking and visualization of cells in vitro and in vivo at an unprecedented resolution, allowing for the first time studies on immune cells under therapeutic influence. This emerging field of research has enormous potential and key importance for next generation of researchers in oncology and beyond. However, experts in this field are missing and this threats European research, development and medicine. Therefore, T-RAFIC joins forces of 13 academic and three industrial partners from nine European countries to conduct an innovative and interdisciplinary approach combining cell imaging with bioinformatics, cell engineering and clinician expertise. The network bundles recognised expertise in cancer immunotherapies, empowering European research and innovation and ensuring a sustainable cooperation in science and training.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine oncology
- medical and health sciences basic medicine immunology immunotherapy
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral Networks
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2023-DN-01
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80539 MUNCHEN
Germany
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Participants (10)
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2800 KONGENS LYNGBY
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1081 HV Amsterdam
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3400 Hillerod
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94805 Villejuif
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75654 PARIS
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6020 INNSBRUCK
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51429 Bergisch Gladbach
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20072 PIEVE EMANUELE
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0450 OSLO
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81675 Muenchen
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Partners (16)
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80333 Muenchen
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6020 Innsbruck
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Participation ended
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CM1 1SQ Chelmsford
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6900 LUGANO
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75006 PARIS
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1165 KOBENHAVN
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0313 Oslo
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35042 RENNES
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1081 HV Amsterdam
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Participation ended
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8952 Schlieren
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6500 Bellinzona
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91190 GIF-SUR-YVETTE
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81377 Munchen
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NG1 1GF Nottingham
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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4123 Allschwil
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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NG1 4FQ NOTTINGHAM
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