Project description
European lipid-related research
Lipids are fundamental components of cell membranes. They form bilayers that regulate cellular interactions and transport. Their ability to self-assemble into complex, functional forms make them ideal for developing nanomaterials that mimic cellular membranes for advanced applications such as targeted drug delivery and biosensing. With the support of the Marie Skłodowska-Curie Actions programme, the CLIMB project aims to explore how the complexity of lipid compositions affects membrane structures, interactions, and emerging collective properties. The project connects leading research labs that will develop and characterise novel lipid mixtures for applications in mRNA delivery, biosensors, and eco-friendly formulations. Furthermore, they will provide new information on fundamental properties of complex lipid self-assembled systems.
Objective
“CLIMB-Complex lipid membranes for science and technology” is a doctoral network of leading European lipid-research laboratories with highly complementary research expertise and training capabilities, which will allow participating PhD students to develop a wide range of research and transferable skills attractive to employers in both academic and industrial sectors.
The research themes focus on the hypothesis that comprehensive understanding of the role of compositional complexity on “yet to be explored” structural properties and membrane-driven interactions is key to developing complex lipid-based nanomaterials that mimic the cellular environment and function as high-performance sustainable materials.
A central aspect of the CLIMB programme is the development and physicochemical characterization of structure and stability of aggregates formed by novel lipid mixtures including natural extracts and novel protective polymer/peptoid-based coatings. Scientific results will be made available to non-academic partners to assess its possible translation into applications in the fields of mRNA delivery, bio-sensor development, and “green” formulations, areas in line with some of the grand challenges identified by EU.
These objectives will be achieved by combining advanced and complementary experimental approaches from chemistry, physics, biology, and computational sciences. Through close collaboration with a network of both small and large industrial partners, the trainees will receive direct hands-on experience, and will gain insights into how lipid-based materials are used in innovative applications.
In summary, CLIMB aims to advance the current knowledge on the interplay between structure, functions, interaction, and compositional complexity in lipid membrane. The generated results will contribute to important knowledge transfer between academia and the companies involved, promoting and increasing the success rate for innovations of grand societal challenges.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensorsbiosensors
- natural scienceschemical sciencespolymer sciences
- natural sciencesbiological sciencesbiochemistrybiomoleculeslipids
- engineering and technologymaterials engineeringcoating and films
- engineering and technologynanotechnologynano-materials
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Programme(s)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Funding Scheme
HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral NetworksCoordinator
00185 Roma
Italy