Objective
The herpesvirus human cytomegalovirus (HCMV), the largest known human virus, is a ubiquitous pathogen that infects the majority of the world's population. Although subclinical in most healthy individuals, HCMV can lead to a severe congenital disease, as well as morbidity and mortality in immunocompromised adults. Despite the high prevalence and pathogenicity of HCMV, numerous fundamental questions about this pathogen remain open. We still do not know what many of its viral proteins do and how they modulate cellular processes, we do not understand the determinants that govern dependencies and vulnerabilities of infection in different cell types, and we are missing tools that facilitate molecular dissection of HCMV in relevant infection models.
In this proposal, we plan to develop and apply unique tool sets to uncover the host pathways and factors that orchestrate HCMV life cycle in different cell types and in higher complexity infection models. We propose to combine state-of-the-art high-throughput tools with mechanistic studies to comprehensively characterize how HCMV proteins perturb central host cellular processes (aim 1), identify HCMV common and cell-specific host dependencies and vulnerabilities in different cell types (aim 2) and develop an advanced platform for probing CMV dependencies in organoid and organism infection models (aim 3).
The knowledge generated from these objectives will provide a comprehensive depiction of the interplay of HCMV with its host and could help expand our therapeutic options. More broadly, with its comprehensive and complementary approaches, our work will provide a paradigm for understanding complex host-pathogen interactions.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- social sciences sociology demography mortality
- natural sciences biological sciences microbiology virology
- natural sciences biological sciences biochemistry biomolecules proteins
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2024-COG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
7610001 Rehovot
Israel
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.