Project description
Pioneering extracellular vesicles for personalised medicine
Extracellular vesicles (EVs) are small, membrane-bound vesicles released by cells into the extracellular environment. They play a crucial role in cell communication by transferring proteins, lipids and RNA between cells. EVs are involved in various physiological and pathological processes, including immune responses, cancer progression and tissue repair. With the support of the Marie Skłodowska-Curie Actions programme, the EVEREST project aims to standardise EV isolation and characterisation. Researchers will investigate the roles of EVs in health and disease, promoting them as biomarkers and drug delivery vehicles. The long-term goal is to advance EV-based therapeutics and position EVs as essential tools for personalised medicine.
Objective
The EVEREST project is a pioneering consortium in Extracellular Vesicle (EVs) research, bringing together 22 institutions from 11 countries, including 3 UK partners. This interdisciplinary consortium is distinguished by an ambitious plan for over 285 months of staff exchanges, engaging at least 81 fellows. Research-Innovation programme is structured into four pivotal work packages:
1. Combining Expertise and Resources for Advancing Standardised Characterisation and Isolation of EVs: Focused on harmonizing methods for EV isolation across diverse tissues and samples, enhancing the consistency and reliability of EV research.
2. Jointly Investigating EVs in Health or Disease, and Enhancing Translational Biomarker Discovery: Concentrated on exploring the roles of EVs in various health conditions and diseases, with a particular emphasis on identifying and validating new biomarkers for diagnostic and prognostic applications.
3. Uniting Capacities, Advancing EV-Based Therapeutics or Drug Delivery: Dedicated to developing innovative EV-based treatments and drug delivery mechanisms, targeting key health challenges like cancer and cardiovascular diseases.
4. Catalysing commercial development of EV-based technologies: Aiming to bridge the gap between research and practical application, this work package focuses on preparing EV-based solutions for large-scale production and market introduction.
At its core, EVEREST is committed to significantly enhancing the capabilities of participating institutions and fostering career advancement for involved fellows. By positioning EVs as critical tools for biomarker discovery and therapeutic applications, the project aims to make substantial contributions to personalized medicine and improved health outcomes, ultimately translating research breakthroughs into clinical practice.
Fields of science
Keywords
Programme(s)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Funding Scheme
HORIZON-TMA-MSCA-SE - HORIZON TMA MSCA Staff ExchangesCoordinator
4 Dublin
Ireland
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Participants (16)
D02 CX56 Dublin
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581 83 Linkoping
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1099 085 Lisboa
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814 99 Bratislava
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4362 Esch Sur Alzette
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223 81 Lund
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
582 16 Linkoping
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
6722 Szeged
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
A96 XV67 Dublin
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
08907 Hospitalet De Llobregat
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
47007 VALLADOLID
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41092 Sevilla
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36310 Vigo Pontevedra
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X91 K0EK Waterford
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35390 Giessen
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LT-08406 Vilnius
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Partners (4)
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
BT7 1NN Belfast
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
NG6 8TQ NOTTINGHAM
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
EC1M 4JN LONDON
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
3590 Diepenbeek
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.