Project description
Glycoprotein arrays for functional surveillance of viruses
The ERC-funded Sugar-Enable project recently developed glycan arrays that identify the minimal receptors for duck, chicken, and human influenza A viruses, enabling early detection of potential pandemic viruses and making a significant societal impact. The project also identified key structures for viruses as intermediate receptors at the avian-mammalian interface. The follow-up ERC project ARRAYED SURVEILLANCE aims to assess the technical and commercial feasibility of these developments. Additionally, it will incorporate proteinaceous receptors for coronaviruses, leveraging experience in printing arrays. This combined ‘glycoprotein’ array will be used for the functional surveillance of two virus families that pose a significant pandemic threat.
Objective
This ERC PoC project aims to establish the technical and commercial feasibility of our recently developed glycan-arrays in which we determined the minimal receptor for duck, chicken, and human influenza A viruses, respectively. We also determined structures vital for viruses as intermediate receptors on the avian-mammalian interface. With our experience in printing arrays, we also want to add proteinaceous receptors for coronaviruses. This mixed glyco-protein array will then be employed for functional surveillance of two virus families with significant pandemic threat. The ERC program sugar-enable has developed different glycan arrays that should be used in the real world to detect potential pandemic viruses as soon as possible, now making a substantial societal impact. In this project, we aim to conduct a technical and commercial feasibility study.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
- natural sciencesbiological sciencesmicrobiologyvirology
- medical and health scienceshealth sciencespublic healthepidemiologypandemics
- medical and health scienceshealth sciencesinfectious diseasesRNA virusesinfluenza
- medical and health scienceshealth sciencesinfectious diseasesRNA virusescoronaviruses
- natural sciencesbiological sciencesbiochemistrybiomoleculescarbohydrates
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Programme(s)
- HORIZON.1.1 - European Research Council (ERC) Main Programme
Funding Scheme
HORIZON-ERC-POC - HORIZON ERC Proof of Concept GrantsHost institution
3584 CS Utrecht
Netherlands