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DNA Encryption of Compartmentalized DNA Files

Project description

Storing encrypted digital data in DNA

Long-term storage of digital data faces significant challenges due to the sustainability limitations of current technologies. Storing data in DNA is an innovative and rapidly developing field that leverages the natural properties of DNA to encode and preserve information. The concept is to encode binary data into sequences of nucleotides (A, T, C, G) and synthesise DNA molecules that represent digital information. This approach offers not only unparalleled storage density but also longevity. The ERC-funded DNACryp project aims to develop a novel molecular encryption method for DNA storage based on the gold standard polymerase chain reaction of DNA amplification. The key objective is to protect data from unauthorised data access.

Objective

Current technologies for digital data storage (e.g. tapes and hard disc drives) have hit various sustainability limits. A significant share of new data is not stored beyond the short term, and conventional storage media do not have the longevity, data density or cost efficiency to meet global demand. Longer-term projections forecast that the overall demand for digital storage will exceed supply by up to three orders of magnitude by 2040. DNA data storage has several advantages compared to magnetic or optical data storage, such as extremely high data densities, high stability, and limited energy needs. Considerable effort has been devoted to developing efficient encoding algorithms and methods for DNA storage and retrieval. However, a complete data storage solution also requires the stored information to be protected from unwanted data access.
In DNA Encryption of Compartmentalized DNA Files (DNACryp), we will develop a novel molecular-level encryption method for data stored on compartmentalized DNA files based on a revolutionary PCR-based random-access readout strategy that our lab has recently developed. In contrast to digital encryption methods, molecular-level encryption is resistant to automated, computer-based attacks. To achieve this goal, DNA files are co-encapsulated with locker DNA templates that disrupt random-access readout. Using a unique, sequence specific key strand, locker templates can be removed, and PCR-based readout restored. Specifically, we will develop (i) an encoding pipeline for data-encoding DNA strands allowing for encryption, (ii) proof-of-principle experiments showing the validity of the locker/key concept, (iii) molecular-level encryption of a 1MB book. DNACryp methodology is highly interdisciplinary building on expertise in computer science, engineering, chemistry, and material science. DNACryp impact spans applications and technology domains and will be disseminated and exploited to benefit European society and industry.

Fields of science (EuroSciVoc)

Programme(s)

Topic(s)

Funding Scheme

HORIZON-ERC-POC - HORIZON ERC Proof of Concept Grants

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Call for proposal

(opens in new window) ERC-2024-POC

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Host institution

TECHNISCHE UNIVERSITEIT EINDHOVEN
Net EU contribution
€ 150 000,00
Address
GROENE LOPER 3
5612 AE Eindhoven
Netherlands
Region
Zuid-Nederland Noord-Brabant Zuidoost-Noord-Brabant
Activity type
Higher or Secondary Education Establishments
Links
Total cost
No data

Beneficiaries (1)