Objective
Malaria eradication efforts are severely hampered by the rapid emergence and spread of resistance in mosquitoes due to widespread use of insecticide-based vector-control tools. Recently, we have published a study proposing a novel malaria intervention strategy based on the use of a bacterial strain, Delftia tsuruhatensis TC1 (TC1 for short) and its secreted active component, Harmane (HA). The TC1-intervention interrupts malaria parasite development in mosquitoes without affecting mosquito survival and fitness thereby circumventing selection of resistant mosquitoes. Extensive studies to evaluate efficacy, safety and manufacturability have been successfully completed in both, laboratory and contained semi-field settings and further validate use of the TC1-intervention for malaria control.
Although, WHO has established product evaluation pathways and regulatory pipelines for insecticide-based vector control tools these are not suited for TC1 and other ‘TC1-like’ control strategies which do not fall within the ‘main-stream’ conventional category of malaria vector-control tools. To date all vector control tools have been evaluated in cluster randomized control trials (RCTs) to demonstrate epidemiological benefit but RCTs are becoming increasingly difficult and extremely expensive to conduct as standard-of-care increases the heterogeneity between clusters, diminishes the effect size of novel interventions thereby requiring higher numbers of clusters to reliably power studies. An urgent need exists for rigorous and validated entomological metrics which infer epidemiological benefit. This project aims to develop a novel trial for generating the evidence base of the TC1-intervention in open-field settings at the scale of the individual mosquito, to help support the regulatory process and expedite the time between product development and widespread deployment. Additionally, this novel trial could be extrapolated to similar interventions for controlling vector-borne diseases.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences infectious diseases malaria
- natural sciences biological sciences zoology invertebrate zoology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.2.1 - Health
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-JU-RIA - HORIZON JU Research and Innovation Actions
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-JU-GH-EDCTP3-2024-01-two-stage
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
28760 Tres Cantos
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.