Objective
Foxp3+ regulatory T cells (Tregs) are highly potent immunosuppressive cells. Most of our understanding of Tregs is based on the population present in lymphoid tissues, however to harness their anti-inflammatory power in the clinic we need to understand the tissue-resident population. Converting generic Tregs into expanded proto-tissue Tregs, capable of entering inflamed tissues, adapting to local conditions, and driving an anti-inflammatory pro-rejuvenation process would transform cell therapy. However to be able to encode a tissue-resident function into Tregs, we first need to decode the cellular induction signals that allow a Treg to become a tissue Treg, and decode the molecular processes of Treg tissue entry and reprogramming into the residential phenotype.
This project seeks to dissect Treg tissue-residency at an unprecedented scale. The applicant’s team has developed and validated cutting-edge technology, “FlowCodes”, to enable massively-parallel functional testing of the tissue Treg repertoire and genetic control. The project will test the cellular behaviour of ~500 tissue Treg TCRs and ~500 gut Treg TCRs through retrogenic TCR analysis, across multiple organs, in health and disease, identifying the site of Treg induction and disease-responsiveness for each. The project will further test ~400 potential genetic cofactors (migration genes, transcription factors, metabolic adaptors), for contribution to tissue residency and potential to aid anti-inflammatory responses. Finally, the project will provide a proof-of-concept for re-encoding the identified residency features, and systematically test combinations of decoded TCR and genetic factors for the ability to augment tissue-residency and disease suppression in Tregs. The project therefore not only unravels the biological rules for Treg residency, it provides a pathway back to Treg cell therapy engineering.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2024-ADG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
CB2 1TN CAMBRIDGE
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.