Objective
Cryo-Electron Tomography (Cryo-ET) is a powerful technique that allows observing the 3D structure of biological molecules in their native cellular environment, and as such, has a unique promise to transform our understanding of biology at the mesoscopic level. Currently, its full impact is constrained by the difficulties associated with interpreting the 3D tomograms in terms of the molecular reality they represent (the so-called assignment problem), which mainly happens due to low resolution and noise inherent to the method.
Our research goal is to develop innovative and highly efficient computational tools that will help to overcome the existing challenges and help to address the assignment problem. We shall achieve this goal by building invariant representations of 3D volumetric data that will allow us to significantly speed up the processing of tomograms and expand the scale and accuracy of the analysis that can be performed. This mathematical foundation will allow us to strengthen both template-based and template-free approaches to the assignment problem, addressing the critical weaknesses of the current state of the art, specifically, the high computational costs of the former and dependence on scarce training data of the latter. To demonstrate the whole capacity of our approach, we shall apply it to novel tomograms of highly important whole-cell biological samples obtained by our experimental collaborators.
This highly multidisciplinary project (math+computation+biology) rests on the unique theoretical/computational competencies brought by the supervisor and the candidate, and involves a key experimental collaboration, bolstering the exchange of scientific knowledge. The planned training of the candidate in mathematical/algorithmic methods, the peculiarities of the Cryo-ET data, and key transversal skills will strengthen his profile as a specialist in integrative molecular modeling and ensure a successful transition to the next career stage.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75794 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.