Objective
The project aims to investigate the mode-of-action of quaternary ammonium compound-based disinfectants (QACs) against Mycobacterium in comparison to the model rod-shaped bacterium, Escherichia coli. Additionally, it seeks to explore the role of phenotypic heterogeneity in the mycobacterial populations response to disinfectant exposure. Inappropriate application of QACs may lead to the emergence of tolerance or resistance to these compounds, and possibly cross-resistance to antibiotics. Currently, there are only a few reports discussing the influence of disinfection on anti-tubercular drugs action. It is hypothesized that the specific composition of the cell wall in mycobacteria, along with the potential ability to modify this composition, and their elongation mode, contributes to high population heterogeneity, which might facilitate the adaptation to the stress imposed by QACs. To address this, the following project objectives are planned: 1) to characterize whether and how single-cell heterogeneity influences the response to QACs in rod-shaped bacteria, and 2) to elucidate the population heterogeneity-derived changes in the tolerance and resistance mechanisms of Mycobacterium against QACs. By using a fluorescently labeled analog of the commonly used benzalkonium chloride (BAC), NBD-DDA, it will be possible for the first time to conduct real-time investigations of the compound's accumulation and its effects on rod-shaped bacterial populations.
The project outcome will shed light on the mechanisms underlying the emergence of tolerance and resistance to disinfectants in Mycobacterium and will help to understand the basis of potential cross-resistance between disinfectants and anti-tubercular antibiotics. Given the recent increase in disinfectant usage and the high annual incidence of mycobacterial infections, studying the potential interactions between these groups of compounds is of great importance and could guide future disinfection and treatment strategies.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology bacteriology
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs antibiotics
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
12205 Berlin
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.