Objective
The oral intake of the food additive E171 (titanium dioxide, TiO2 nanoparticles) has raised significant public health concerns due to its potential adverse health effects. It was recently banned in the European Union after a reassessment by the European Food Safety Authority (EFSA) due to genotoxicity risks. However, it is still widely used in many countries, and the mechanisms underlying E171's toxicity, particularly its effects on the liver, remain poorly understood. The LiTiTox project aims to address this by investigating the molecular mechanisms of E171-induced liver toxicity, focusing on inflammation, cell death, and the role of pannexin1 (Panx1) channels, which are crucial for inflammasome activation but remain unexplored in this context. LiTiTox will employ a multidisciplinary approach, combining advanced in vitro liver spheroid co-culture models, in vivo mouse studies, and in silico molecular simulations. Liver spheroid models will simulate human liver responses to TiO2 exposure, while in vivo mouse studies will explore the effects of oral E171 exposure on liver toxicity. Molecular docking and dynamics simulations, conducted during the secondment, will predict interactions between E171 TiO2 and liver toxicity-related molecular events (MIEs). The project will also equip the researcher with advanced skills in in vitro toxicology, experimental hepatology, molecular biology, and computational modelling, enhancing career development and leadership in scientific research. The secondment will provide specialised training in chemoinformatics, machine learning, and predictive toxicology. Ultimately, LiTiTox’s findings will offer a deeper understanding of how E171 TiO2 nanoparticles affect liver health, contributing to the development of global regulatory policies. LiTiTox will play a crucial role in promoting food safety, sustainable nutrition, and safeguarding public health.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences inorganic chemistry transition metals
- medical and health sciences health sciences nutrition
- medical and health sciences clinical medicine hepatology
- engineering and technology nanotechnology nano-materials
- medical and health sciences basic medicine toxicology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1050 BRUSSEL
Belgium
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.