Objective
Obesity prevalence is dramatically increasing worldwide. The hypothalamus seem to be a pivotal brain structure in reversing obesity, as hypothalamic activation by incretin-based therapies (IBT) reduces body weight by 25%. However, the detailed functioning of the human hypothalamus in obesity remains unknown.
Therefore, my overarching objective is to characterize hypothalamic structure and function in obesity. I will collaborate with clinical obesity experts at the University of Copenhagen and a pioneering MRI research team at Brigham and Women’s Hospital.
The project includes three Work Packages (WPs), each addressing a gap in current state-of-the-art knowledge:
WP1: Impact of IBT on hypothalamic signaling
Hypothesis: IBT partially or fully normalizes meal-induced hypothalamic signaling to reverse obesity.
Sub-objective: Map how long-term IBT affects hypothalamic signaling to the rest of the brain in a large randomized controlled trial of youth with obesity.
WP2: Exploring the Impact of Oxytocin on Hypothalamic Structure and Function
Hypothesis: Oxytocin reduces radiological indicators of hypothalamic inflammation associated with obesity and improves hypothalamic function.
Sub-objective: Characterize hypothalamic structure and function in obesity and map the effects of four weeks of intranasal oxytocin treatment.
WP3: Hypothalamic Responsiveness to Incretin Hormones
Hypothesis: Hypothalamic responsiveness to incretin hormones is impaired in obesity.
Sub-objective: Map the responsiveness of the hypothalamus to incretin hormones in people with obesity compared to people without obesity.
The output of this project will elucidate key neurobiological mechanisms underlying obesity and inform the development of sustainable strategies to treat and prevent obesity. It will also facilitate critical knowledge exchange between European and U.S. research institutions and significantly advance neuroendocrine research capacity in Europe.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-GF - HORIZON TMA MSCA Postdoctoral Fellowships - Global Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1165 KOBENHAVN
Denmark
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.