Objective
TIMNano is focused on Computer-Aided Drug Design (CADD) methods and bioinformatics to identify unique molecular fingerprints associated with gastrointestinal (GI) cancers using 3D-bioprinted patient-derived tumors. The project integrates nanotechnology, bioinformatics, immunology, and cancer biology to develop a novel platform utilizing immune cell-targeted biodegradable polymeric nanoparticles (NPs) aimed at enhancing therapeutic efficacy by inducing tumor destruction following optimal T- and B- cell activation.
The Targeted Nano-immune Modulator (TNM) platform specifically targets local dendritic cells (DCs) to boost T cell-DC chemotaxis within lymph nodes, thus initiating a robust systemic anti-tumor immune response. This approach combines two complementary tumor-killing strategies. Unlike conventional cancer immunotherapies, TNM stimulates both cytotoxic T cells and powerful B cells, which differentiate into long-lived memory T and B cells, as well as antibody-secreting plasma cells capable of producing high-affinity antibodies.
TIMNano aims to progress through the five stages of product development including Good Manufacturing Practice (GMP) production (with technology transfer and scale-up already accomplished), non-clinical efficacy, safety, and toxicokinetic studies, using industrial-scale products within the first 2 years. This will be followed by the subsequent filing of an Investigational Medicinal Product Dossier (IMPD) with the European Medicines Agency (EMA) and then a Phase 1/2 clinical trial will be initiated in the third year of the project.
Funding and support from the European Innovation Council (EIC) will be critical in founding a spin-off company and securing additional investments from private investors, venture capital and investment banks, crucial to further complete the clinical development program by ourselves or upon merger and acquisition deal with a larger Pharma company.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine medicinal chemistry
- medical and health sciences clinical medicine oncology
- engineering and technology nanotechnology nano-materials
- medical and health sciences basic medicine immunology immunotherapy
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.3.1 - The European Innovation Council (EIC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-EIC - HORIZON EIC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-EIC-2024-TRANSITION-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
69978 Tel Aviv
Israel
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.