Project description
Personalised reproductive health support for young cancer survivors
Adolescents and young adults (AYAs) who are cancer survivors face challenges related to their reproductive health, sexuality, and quality of life. The EU-funded PredictAYA project will improve our understanding of the long-term effects of cancer treatment on AYAs aged 15-39. The project will use data from population registries, genomic biobanks, and clinical cohorts. It will focus on capturing patients’ perspectives regarding their care preferences and the psychosocial impacts of treatment. It will develop biomarkers to identify individuals at high risk of organ toxicities, facilitating personalised screening and counselling. Additionally, the study will investigate reproductive toxicity, using precision medicine to explore genetic factors that contribute to treatment-induced toxicity. This initiative is part of the Cancer Mission.
Objective
PredictAYA is a multidisciplinary effort to fully address and improve the understanding of late effects in AYAs 15-39 years treated for cancer, by building on data from existing populations-based registers, large genomic biobanks and newly established clinical AYA cohorts. Importantly, the patient perspective will be captured in our clinical cohorts and patients’ care preferences and needs including the psychosocial impact of cancer treatment on reproductive health, sexuality and quality of life in AYAs. By cooperation between clinicians, researchers, psychologists, oncology nurses and with patient involvement, the study will use a participatory research approach and develop in co-creation with representative AYAs with cancer. This action is part of the Cancer Mission cluster of projects on “Quality of life (AYA).
Our long-term goal is to develop a panel of validated biomarkers to identify individuals at high-risk of organ toxicities, aiming at clinical implementation and future individualized screening and counselling. Our main focus is on reproductive toxicity and through innovative precision medicine and pharmacogenetics, we will identify genetic biomarkers explanatory for interindividual variation in treatment induced toxicity among AYAs. A model on constitutional genetic risk for reproductive organ toxicity will be evaluated in clinical cohorts across Europe. Future precision-medicine applications and clinical implementation are envisaged as potential benefit of our proposal.
Additional research questions include the prevalence, severity and timing of gonadal toxicity for different cancer treatments in both sexes, the timing and risks of pregnancy, the risk of accelerated aging, the health of the children born to AYAs. The safety and efficacy of fertility preservation methods will be investigated in detail. Our methodology will also allow us to investigate additional phenotypes and find associations among reproductive, endocrine, cardiac and neurologic toxicity, risk factors including social and health determinants and comorbidity patterns.
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Keywords
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Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.2.1 - Health
MAIN PROGRAMME
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Topic(s)
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Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-RIA - HORIZON Research and Innovation Actions
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Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MISS-2024-CANCER-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
171 77 STOCKHOLM
Sweden
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Participants (17)
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50121 Florence
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EH8 9YL Edinburgh
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51005 Tartu
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581 83 Linkoping
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1066 CX Amsterdam
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1050 BRUXELLES
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LS2 9JT Leeds
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16132 Genova
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1040 Bruxelles / Brussel
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51010 TARTU
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75654 Paris
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69120 Heidelberg
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6020 Innsbruck
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Participation ended
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10117 Berlin
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20133 Milan
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104 22 Stockholm
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04109 Leipzig
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Partners (1)
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3012 Bern
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