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Smart Nanoreactors for Enhanced Electrochemiluminescent Biosensing

Objective

Electrochemiluminescence (ECL) is luminescence driven by electrochemical reactions, offering unparalleled spatiotemporal control and exceptionally low background noise compared to other optical methods. Over the past two decades, ECL has become a powerful analytical tool, revolutionizing areas ranging from fundamental research to clinical diagnostics, biosensing, and biological applications. Despite these significant advancements, understanding the fundamental mechanisms behind ECL remains a complex and ongoing challenge. Creating confined reaction environments at the nanoscale offer a promising tool to unlock new insights into ECL mechanisms. Key questions in this context are:
i) Can we establish a connection between the design of nano electrodes and their nanoconfinement performance in ECL?
ii) Can such a connection be a tool capable of simulating various ECL reactions to optimize reaction parameters?
iii) Can this model help identify the optimal microenvironment to maximize ECL efficiency?
NANO-BOOST will answer these questions by exploring the combined effects of nanoscale geometry and surface chemistry on ECL efficiency with the goal of developing advanced smart ECL Nanoreactors (ECL-NR). Using high-throughput nanofabrication techniques that enable precise control over surface topography and chemistry, NANO-BOOST will bridge the gap between material science and chemistry, creating new synergies to accelerate the discovery of new aspects of ECL mechanisms. NANO-BOOST will establish a definitive correlation between nanostructure design, nanoconfinement, and reaction parameters, thereby pinpointing the optimal conditions to maximize ECL efficiency within specific analytical contexts. These discoveries will contribute to the advancement of high-performance ECL sensing platforms with applications across various scientific domains, such as diagnostics, imaging, and bioanalytical research, consequently propelling early and precise disease detection capabilities.

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Keywords

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Programme(s)

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Topic(s)

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HORIZON-ERC - HORIZON ERC Grants

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Call for proposal

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(opens in new window) ERC-2025-STG

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Host institution

UNIVERSITA DEGLI STUDI DI PADOVA
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 1 498 842,00
Address
VIA 8 FEBBRAIO 2
35122 PADOVA
Italy

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Region
Nord-Est Veneto Padova
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 1 498 842,00

Beneficiaries (1)

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