Objective
Lysosomes are the central degradative organelle of all cells and function as logistic centres of cellular metabolite flux. Their dysregulation underlies ~70 monogenetic lysosomal storage disorders, metabolic syndromes, neurodegenerative maladies, and aging, thus affecting an ever-growing portion of the human population. A frequent denominator in these pathophysiological conditions is the deposition of lipids and lipid metabolites in the lysosomal lumen which leads to the accumulation of dysfunctional lysosomes, inflammatory responses, and cell death. The molecular mechanisms governing lipid flux through lysosomes are poorly understood, despite their importance for human disease. My proposed project will provide fundamental insights into the regulation of lysosomal lipid metabolism and thus pave the way for new therapeutic strategies. To achieve this, I will address two key aspects of lysosomal lipid logistics with direct implications in lysosomal lipid-dependent diseases: First, I will systematically interrogate the poorly understood mechanisms that establish and maintain the specialized lipid composition of the lysosomal limiting membrane. Second, I will uncover mechanisms that regulate the export of lipids and their metabolites from the lysosomal lumen into the cytoplasm. Finally, I aim to harness the findings to boost lysosomal membrane biogenesis and upregulate lipid metabolite export pathways to counteract pathologic lysosomal phenotypes in neurodegeneration-driving microglia cells. The results will provide unprecedented insight into the regulation of lysosomal lipid metabolism and will inform novel strategies to alleviate pathological phenotypes in human diseases with utmost societal importance.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2025-STG
See all projects funded under this callHost institution
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
6020 INNSBRUCK
Austria
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.