Objective
Every tumor is a distinct disease entity, characterized by a unique cellular and molecular profile specific to each individual patient, resulting in varying responses to targeted therapies. Genomics technologies currently pioneer personalized medicine approaches to match patients to optimal therapies, yet most therapeutics aim to alter the activity of proteins rather than genes. At the same time, understanding of the functional consequences of genetic aberrations on drug action has remained elusive. My goal is to bridge this gap by directly assessing how drugs act on a patient’s tumor proteome, a close proxy of cellular function. Leveraging ultra-sensitive mass spectrometry-based phosphoproteomics, my first objective is to develop and benchmark a first-of-its-kind framework for measuring the response of peripheral blood mononuclear cells to drug perturbations (PerturbPhos). We will apply PerturbPhos to a cohort of acute myeloid leukemia (AML) patients to demonstrate that drug-induced perturbations are personal and reflect the individual’s disease background. Moreover, I hypothesize that ex vivo perturbations functionalize a patient’s phosphoproteome, which will allow us to investigate patient-specific mechanisms of drug action and associate many previously uncharacterized phosphorylation sites in the human proteome with drug response. We will perform a CRISPR-mediated based editor screen to functionally validate the latter at scale. The third objective is to demonstrate, on the example of AML patients, that computational integration of PerturbPhos profiles with clinical data, public databases and literature can rationalize treatment recommendations. Collectively, these results will shed mechanistic light on drug response heterogeneity, underscore the potential of proteomics to provide actionable insights for treating individual cancer patients and advocate for adopting a multi-omics perspective in precision medicine.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- natural sciences computer and information sciences databases
- medical and health sciences health sciences personalized medicine
- medical and health sciences clinical medicine oncology leukemia
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2025-STG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
07747 JENA
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.