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A foundational AI-MRI framework for self-supervised discovery of transformative low-field MRI techniques

Objective

Magnetic resonance imaging (MRI) is crucial to healthcare for its radiation-free, high-quality scans, but its high cost leaves 70% of the global population without access. Emerging low-field MRI technology offers affordable, portable systems with transformative potential, but faces critical challenges: long scan times, low signal-to-noise ratio (SNR), and poor tissue contrast, which makes some tissues indistinguishable. Although contrast agents help, they add risks. Early studies showed that low-field MRI can detect cancer without contrast agents using unique pulse sequences, but those are manually designed and slow. Recently, AI has been adopted for clinical high-field MRI, but AI pulse-sequence optimization relies on supervised learning, limiting discovery, AI theory is scarce, and simulations do not fully capture MRI’s complex spin dynamics. Moreover, AI use in low-field MRI remains mostly focused on image post-processing, while pulse sequence design, sampling, and reconstruction remain traditional and suboptimal.

I propose to develop a foundational AI framework that will transform low-field MRI into a rapid, high-quality modality. To break the barriers posed by supervised AI and simulations, my key innovation is an integrated AI-MRI framework, where on-the-fly MRI measurements guide a self-supervised AI search through the parameter space. Leveraging AI foundations I have recently developed, the framework will jointly optimize pulse sequences, sampling, and reconstruction to revolutionize imaging. Specific aims: (1) speed up MRI by an order of magnitude; (2) establish AI theory; (3) build the framework and develop cutting-edge sequences for optimal tissue contrast; and (4) demonstrate these in human scans with my lab’s low-field MRI. Preliminary results support the feasibility of our design aims. This project will transform low-field MRI into a fast, affordable, contrast-agent-free tool with broad clinical applications, particularly in low-income regions.

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Keywords

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Programme(s)

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Topic(s)

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HORIZON-ERC - HORIZON ERC Grants

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Call for proposal

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(opens in new window) ERC-2025-STG

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Host institution

TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 1 812 500,00
Address
SENATE BUILDING TECHNION CITY
32000 Haifa
Israel

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Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 1 812 500,00

Beneficiaries (1)

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