Project description
Transforming bio-based chemical production
The production of bio-based chemicals has long been crucial to various sectors and industries, affecting agriculture, medicine and more. Its complexity has made manufacturing processes difficult, making sustainable production often economically unviable. The EIC-funded C5 project will transform the production of bio-based chemicals, maximising photosynthetic CO2 fixation and converting it into the versatile chemical feedstock molecule isoprene with high efficiency. The project will achieve this by developing disruptive technologies that pioneer the next generation of metabolic engineering, introducing the construction of synthetic cellular organelles in photosynthetic cyanobacteria. In combination with a novel bio-product harvesting technique that eliminates the need for costly biomass collection, the C5 consortium will drive critical innovations to make sustainable biomanufacturing of chemicals economically feasible.
Objective
The C5 Pathfinder project aims to revolutionize the production of bio-based chemicals by leveraging synthetic compartmentalization and metabolic engineering within photosynthetic cyanobacterial systems. The multidisciplinary consortium brings together experts from diverse fields, including microbiology, synthetic biology, and chemical engineering, with the overarching goal to maximize cyanobacterial photosynthetic CO2 fixation and isoprene product generation. This will be achieved by installing a more efficient CO2 fixation cycle, connecting it directly with isoprene production to maximize carbon partitioning, and constructing a conceptual novel synthetic bacterial organelle, co-localizing selected enzymes. This promotes substrate channeling and creates a favorable microenvironment to enhance their catalytic activity while minimizing metabolic crosstalk with the cytosol and containing toxic intermediates. We will develop a process to directly harvest isoprene from the gas phase, which spontaneously separates from the cells and growth media. This avoids problematic biomass harvesting and product extraction, simplifying the production process. The project's success will be assessed through life cycle assessments (LCA) and techno-economic analyses (TEA) to ensure that the developed processes are both environmentally sustainable and economically viable. The collaboration among consortium members will facilitate knowledge transfer and technology development, leading to the creation of modular and scalable systems suitable for industrial applications. Additionally, workshops and outreach activities will be conducted to disseminate findings and promote engagement with stakeholders across the bioeconomy sector. Overall, C5 aims to introduce groundbreaking innovative technologies which will significantly increase Solar-to-Isoprene conversion efficiency and pave the way for the widespread adoption of bio-based chemicals, contributing to a sustainable and circular economy.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology
- agricultural sciences agricultural biotechnology biomass
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.3.1 - The European Innovation Council (EIC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-EIC - HORIZON EIC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
HORIZON-EIC-2024-PATHFINDERCHALLENGES-01
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-EIC-2024-PATHFINDERCHALLENGES-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
14005 CORDOBA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.