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Right-time Adaptive Particle Therapy Of canceR - Personalisation through anatomical plus biological adaptation

Project description

Adapting cancer therapy to the patient

Effective cancer therapy can mean the difference between life and death, but it must be precise. Proton therapy (PT), a highly targeted form of radiotherapy, offers that precision by hitting tumours while sparing healthy tissue. Unfortunately, even small anatomical changes during treatment can throw it off course. Supported by the Marie Skłodowska-Curie Actions programme, the RAPTORplus project is developing real-time adaptive PT to overcome this problem. By training doctoral researchers across academia, hospitals and industry, the project is building the expertise needed to personalise and adjust treatment as it takes place. With cutting-edge tools like image-based biomarkers and AI models, RAPTORplus aims to make PT safer, smarter and more responsive, advancing cancer care for the patients who need it most.

Objective

The RAPTORplus consortium gathers excellent research institutions, academic hospitals and non-academic particle therapy (PT) centres, industrial corporations and public organisations. It offers a platform for intercultural, interdisciplinary and inter-sectoral training and education of doctoral candidates (DCs) in the field of medical physics focussing on right-time adaptive PT. The assembled infrastructure and expertise from academia, clinic and industry is needed to address the challenges of personalised adaptive PT.
PT is a precise form of radiotherapy with a growing number of centres treating patients. It targets localised cancers while sparing healthy tissue, but might deliver suboptimal doses in case of anatomical changes. To exploit the full potential of PT, fast and safe online treatment adaptations must be enabled and performed if beneficial, e.g. indicated by image-based biomarkers, biological models or other response data. The research projects conducted at academic and non-academic facilities will tackle (1) the efficient realisation of online-adaptive PT (OAPT), (2) the technological completion for broad and safe use of OAPT, and (3) a further treatment personalisation by biomarker-based adaptation.
The network uses a multi-sectoral approach to ensure that the DCs develop scientific, clinical and practical industry-relevant skills. The holistic training programme includes in-person training camps, online trainings, project-specific secondments, training in tutoring, research communication, entrepreneurship and science policy, and opportunities to participate in international conferences and professional networks. RAPTORplus will train the next generation of research leaders, medical physicists and entrepreneurs to be aware of the necessity of right-time adaptive PT. They will drive innovation in the coming era of adaptive PT and improve cancer care through enduring international and cross-sectoral collaborations based on their transformative thinking.

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Keywords

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Topic(s)

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HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral Networks

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Call for proposal

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(opens in new window) HORIZON-MSCA-2024-DN-01

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Coordinator

HELMHOLTZ-ZENTRUM DRESDEN-ROSSENDORF EV
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 290 272,32
Address
BAUTZNER LANDSTRASSE 400
01328 Dresden
Germany

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Region
Sachsen Dresden Dresden, Kreisfreie Stadt
Activity type
Research Organisations
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Total cost

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Participants (14)

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