Project description
AI-driven multi-parametric enzyme and bioprocess design
Biocatalysis, the use of enzymes for chemical transformations, offers an alternative for the sustainable manufacturing of drugs, chemicals and materials. Thanks to directed evolution, enzymes can be tailored with improved functions. However, bioprocess scalability is limited by a poor understanding of enzyme function and by the so-called ‘valley of death’ or funding gaps between basic and applied research. With the support of the Marie Skłodowska-Curie Actions programme, the ELEGANCE project aims to establish an academic training programme based on experimental and computational methodologies, such as data science and AI, to engineer integrated multi-parametric enzymes and bioprocesses. Its key objective is to prepare the next-generation specialists with the necessary hard and soft skills to advance data-driven biocatalysis and accelerate bioprocess development.
Objective
Currently, our world is facing several global challenges like climate change, water pollution, land erosion, resource depletion and unsustainable manufacturing. Biotechnology can provide many solutions to these problems. One example is the development of sustainable bioprocesses, which is at the heart of the EU’s green deal. Enzymes are nature’s catalysts at the core of such transformation since they can catalyse complex biocatalytic reactions. Biocatalysis has been slowly but gradually displacing traditional organic chemistry in several processes by virtue of its better efficacy, with the added value of being less wasteful as evidenced by the cornucopia of EPA Green Chemistry Awards conferred to enzymatic processes. Thanks to protein directed evolution (Nobel Prize 2018), enzyme function can be tailored to new-to-nature industrial conditions within bioreactors. However, there are still many challenges limiting bioprocess scalability, owing to a lack of deep understanding of enzyme function and of efficient strategies to overcome the complex multi-factorial optimisation problem of both enzymes and bioprocesses. To address this gap, also known as the valley of death (i.e. a large investment gap between fundamental and applied research), ELEGANCE will offer a unique educational program combining state-of-the-art experimental and computational approaches including data science and artificial intelligence to design better enzymes and bioprocesses faster. The main goal is to train a new generation of specialists with essential hard and soft skills for transforming biocatalysis into a data-driven discipline to accelerate bioprocess development, thereby anticipating potential challenges arising in the valley of death. ELEGANCE will focus on enzymes catalysing highly selective oxyfunctionalisation reactions, unattainable through existing chemical technology, with ecological and economic attractiveness to enable the transition to a circular bioeconomy in many industries.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology environmental biotechnology bioremediation bioreactors
- natural sciences earth and related environmental sciences environmental sciences pollution
- social sciences economics and business economics bioeconomy
- natural sciences chemical sciences catalysis biocatalysis
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral Networks
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-DN-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
2800 KONGENS LYNGBY
Denmark
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Participants (12)
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10124 TORINO
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28006 MADRID
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8010 Graz
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The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
17004 GIRONA
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2628 CN DELFT
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10000 ZAGREB
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8000 Aarhus C
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601 77 Brno
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14195 BERLIN
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160 00 PRAHA
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97490 La Bretagne - Sainte-Clotilde
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The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.
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20123 MILANO
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Partners (15)
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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70174 Stuttgart
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H3T 1J4 MONTREAL
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8010 Graz
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The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
28341 MADRID
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
13355 Berlin
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
2880 Bagsvaerd
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
91160 Longjumeau
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
151 85 Sodertaelje
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
17165 Stockholm
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
8010 Graz
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
28049 MADRID
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The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
8010 Graz
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The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
44000 Nantes
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BS8 1QU BRISTOL
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35122 PADOVA
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