Project description
Training for effective wound treatment
Wound healing restores skin integrity after injury but can be hindered by factors such as size, location, and comorbidities. Chronic wounds affect about 6 % of adults and are expected to increase, while current treatments are often ineffective. With the support of the Marie Skłodowska-Curie Actions programme, the REMOD-HEALING project aims to address pathological wounds by utilising therapeutic targets and biomarkers related to extracellular matrix (ECM) remodelling. It will analyse and target abnormal ECM changes caused by proteolytic enzymes in healing disorders such as chronic ulcers and epidermolysis bullosa. Specifically, partners from Europe and Latin America will train doctoral candidates while conducting research to deepen the understanding of proteolytic networks in wounds.
Objective
Wound healing is a physiological process leading to the restoration of the skin barrier integrity after injury. A large number of factors (wound size and location, exogenous pathogenic agents, aging, co-morbidities, genetic diseases) can affect wound healing and prevent its normal resolution, leading to wounds that never heal (i.e. chronic wounds) or that heal in an aberrant manner (e.g. with scarring or dermonecrosis). Wound healing disorders affect up to 6% of the adult population in the world and this number is expected to continue to grow due to population aging and increasing incidence of metabolic diseases. In addition, current therapeutic solutions lack efficiency and there is an urgent need for better diagnostic tools to improve wound management. In the REMOD-HEALING project, we propose to tackle the burden of pathological wounds by exploiting the huge reservoir of therapeutic targets and biomarkers associated with extracellular matrix (ECM) remodelling in cutaneous wounds. Our innovative approach will be to analyse, model and target the aberrant ECM modifications induced by proteolytic enzymes in various healing disorders (chronic ulcers, epidermolysis bullosa, snake bite-induced dermonecrosis) with the hypothesis that the quality of the ECM shaped by proteases dictates the quality of tissue regeneration. We have gathered a team of 14 European and Latin American partners to provide excellent training to 12 doctoral candidates and generate breakthrough research allowing us to (i) gain a deeper understanding of proteolytic networks in normal and pathological wounds in order to identify novel potential biomarkers and protease targets (Objective 1), (ii) obtain biochemical and structural information on specific protease targets, their ECM substrates and their endogenous inhibitors to fuel the discovery of diagnostic tools and anti-protease drugs (Objective 2), (iii) develop new diagnostic and therapeutic tools to improve wound management (Objective 3).
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
This project's classification has been human-validated.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
This project's classification has been human-validated.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral Networks
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-DN-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75794 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.