Objective
Epilepsy is one of the most common neurological disorders in the European Union (EU) and is characterized by unpredictable interruptions of brain functions, known as epileptic seizures. In drug-resistant epilepsy, the most effective path to seizure freedom is epilepsy surgery, which targets the removal of the Epileptogenic Zone (EZ), the brain area responsible for seizure generation. The localization of the EZ can be aided by Stereo-Electroencephalography (SEEG), a presurgical intervention that records brain activity in cortical and subcortical areas via intracranial electrodes. SEEG signals are highly complex to interpret, and the success rate of epilepsy surgery remains below 70% despite recent technological advancements. The identification of new biomarkers of the EZ is thus an essential priority for the medical community and the European Reference Network for Rare and Complex Epilepsies. With this aim, the HYPHEN project will develop a new framework for analysing SEEG data. The project will be among the first to represent SEEG signals as hypergraphs, in which each SEEG channel is modelled as a node and connections between multiple nodes are captured via high-order interactions. This approach will make it possible to identify epileptogenic channels and infer the presence of epileptogenic structures not sampled by the SEEG implant. In the latter cases, HYPHEN will design a graph-completion strategy to predict hidden epileptogenic nodes, enabling epilepsy surgery in scenarios currently considered too complex for treatment. These activities will be conducted at Aix-Marseille University (France), under the supervision of Prof. Bénar, in close collaboration with Prof. Bartolomei, two world leaders in the field of SEEG analysis. Complementary methodological expertise will be provided through a secondment at Northeastern University London (UK), in the laboratory of Prof. Petri, a leading authority in high-order networks and their application to neuroscience.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- medical and health sciences basic medicine neurology epilepsy
- medical and health sciences clinical medicine surgery
- natural sciences mathematics pure mathematics discrete mathematics graph theory
- medical and health sciences medical biotechnology implants
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-PF
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
13284 Marseille
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.