Project description
Redox signals and mitochondrial health
Mitochondria are the energy-producing structures of cells and also a major source of reactive oxygen species (ROS). Once seen mainly as harmful, ROS species are now known to act as important signals. When ROS levels become unbalanced, they can damage cells and contribute to mitochondrial diseases, neurodegeneration and cancer. However, the molecular links between mitochondrial dysfunction and redox signalling remain poorly understood. With the support of the Marie Skłodowska-Curie Actions programme, the MitoSwitch project will investigate how reversible protein oxidation acts as molecular switches controlling mitochondrial metabolism. Using advanced redox proteomics, the research team will uncover disease mechanisms and develop new tools for understanding health and pathology.
Objective
Reactive oxygen species (ROS) are increasingly recognized as important regulators of cellular signaling, with hydrogen peroxide acting as a key mediator through reversible protein oxidation (redox switches). Mitochondria are the major source of ROS during oxidative phosphorylation, and disturbances in redox balance are a hallmark of mitochondrial diseases, which contribute to both rare inherited disorders and common conditions such as neurodegeneration and cancer. Despite advances in diagnosis, therapeutic progress remains limited, in part because the molecular mechanisms linking mitochondrial dysfunction, redox signaling, and disease progression are poorly understood. This project, MitoSwitch, addresses this knowledge gap by investigating how redox regulation shapes mitochondrial metabolism. I will generate redox proteomic data using two complementary approaches: (i) a model of mitochondrial disease with disrupted redox balance, and (ii) spatially resolved oxidation patterns reflecting local mitochondrial activity. Selected candidate oxidations will then be functionally assessed to identify novel redox switches controlling mitochondrial metabolism. By bridging cellular and tissue-level perspectives, MitoSwitch will advance our understanding of redox biology, reveal molecular mechanisms underlying mitochondrial disease, and deliver broadly applicable methodologies for studying redox regulation in health and pathology.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences chemical sciences electrochemistry electrolysis
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine oncology
- medical and health sciences basic medicine pathology
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-PF
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
171 77 STOCKHOLM
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.