Objective
Atrial fibrillation (AF) is projected to affect one in three adults by 2060 . Patients with AF are at increased risk of heart failure (HF) and death. Indeed, more than half (57%) of subjects with new-onset HF already have AF and are associated with higher hospitalisation and mortality rates. Remarkably, AF alone represents 2% of the global healthcare expenditure.
Catheter ablation is the most effective therapy for AF patients. However, 50% of patients experience recurrence after the first ablation, requiring additional and more extensive ablations. Paradoxically, while an extensive ablation lesion might be more effective for preventing AF, it could also result in atrial mechanical dysfunction, increasing the risk for HF. Thus, the ability to accurately identify patients in which ablation could lead to HF, and stratify them to optimal treatments to reduce the risk of both diseases would be of tremendous clinical value.
In this fellowship, I propose to address the unmet need of personalising AF therapy to minimise the risk of HF (AFHF-TAILOR) by integrating whole-organ computer simulations powered by artificial intelligence (AI) and clinical data. The project takes in-silico studies to the next level, by integrating electro-mechanical simulations in thousands of virtual patients. Moreover, to ensure that the computer framework meets the needs for clinical translation, a dedicated AI framework will be trained on the simulations to enable rapid and accurate estimations of personalised cardiac mechanics. Two distinct clinical datasets, with important information such as cardiac imaging, catheter ablation lesions and mechanical biomarkers, will be used to externally validate the AI algorithm and the computer simulations. Accordingly, the project will provide a robust digital framework that balances ablation efficacy with the preservation of atrial function, ultimately reducing the risk of both diseases, AF and HF.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-PF
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
8092 Zuerich
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.