Objective
The precise regulation of gene expression is essential for embryogenesis. Transposable elements (TEs), often considered genomic parasites, are hypothesised to function as regulatory hubs coordinating gene networks during this critical window, but evidence remains largely correlational. The RegulatoryTEmbryo project will bridge this gap by dissecting the causal impact of regulatory TEs on Arabidopsis thaliana development.
This project moves beyond correlation to establish causation through an integrated experimental strategy. First, I will use a dedicated bioinformatic pipeline and in vivo reporter assays to identify and validate the regulatory function of specific TE families. Second, I will employ multiplexed CRISPR-Cas9 to perform targeted deletions of these families, allowing for a definitive assessment of their impact on embryonic transcription and phenotype. Finally, I will use biochemical assays (EMSA) to mechanistically confirm the underlying transcription factor-TE interactions, and evolutionary approaches to uncover the general principles governing TE-encoded gene regulation in plant embryo patterning.
This research will deliver a new model for the role of TEs as key drivers of developmental gene regulation. Ultimately, it will provide a mechanistic framework for understanding how TE-encoded gene regulatory activity fuels morphological diversity in nature. By integrating advanced cell biology and biochemistry with my expertise in epigenomics, this fellowship will provide the crucial interdisciplinary skills required to launch my career as an independent research leader.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry
- medical and health sciences clinical medicine embryology
- natural sciences biological sciences genetics epigenetics
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-PF
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75794 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.