Project description
Neuroimmune control of food allergy and immunotherapy response
The treatment for food allergies is based on prevention and intervention. Oral immunotherapy often fails to provide lasting protection. Supported by the Marie Skłodowska-Curie Actions programme, the AllergyREBELL project explores the role of gut nerve cells in regulating immune responses. By using advanced imaging and spatial multi-omics in murine models, the project maps the complex communication between the nervous and immune systems in the small intestine. This research into how neural signals influence immune cell behaviour aims to shed light on why immunotherapies succeed or fail. Overall, the project seeks to translate these insights into safer, more effective therapeutic strategies.
Objective
Current management of potentially life-threatening food allergy (FA) relies on strict food avoidance and emergency medications such as ephedrine auto-injectors for acute reactions. Although oral allergen immunotherapy (OIT), gradual updosing of the offending food, has shown great promise in inducing oral tolerance, these effects are often transient and patients with severe initial symptoms are frequently non-responders. Thus, there is a pressing need for improved OIT protocols. Neuro-immune dialogue shapes the immune response in allergic asthma: activation of lung-innervating sensory neurons (nociceptors) by allergen exposure amplifies allergic lung inflammation. Comparably, gut-innervating nociceptors can also be activated through allergen exposure, pointing toward a similar neuro-immune dialogue in FA. It is currently unclear how nociceptors communicate with immune cells in FA and how this communication influences OIT outcome. In AllergyREBELL, I will identify crucial neuroimmune circuits for FA maintenance and tolerance induction by (1) constructing neuroimmune communication maps in the small intestine using a murine FA mouse model in combination with spatial transcriptomics, spatial lipidomics coupled to proteomics and intravital microscopy to track immune cell movements, (2) determining the modulatory capacity of neural factors using a sophisticated immune cell co-culture model and (3) characterising activation profiles of allergy-relevant nociceptors upon allergen exposure. This project will provide a multi-omics atlas on neuroimmune communication in FA as well as first insights how this communication modulates immune responses critical for tolerance induction. My paramount goal with AllergyREBELL is to identify crucial neuroimmune axes, which can be potentially exploited as therapeutic add-ons to improve OIT for non-responding patients and thus, increasing patients’ quality of life by reducing their constant fear of accidental exposures.
Fields of science (EuroSciVoc)
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CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-PF
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
171 77 STOCKHOLM
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.