Objective
T cell–driven inflammatory diseases like multiple sclerosis (MS), are a leading cause of global mortality. This project seeks to harness recent advances in the anti-inflammatory mechanisms of innate immune memory (IIM) and my expertise in vaccinology to develop innovative strategies against these conditions. Innate immune cells can be reprogrammed through trained immunity (TI), enabling them to mount stronger and sustained responses upon re-stimulation. In vaccinology, adjuvants or adjuvant components (ACs) like β-glucan can trigger such effects. Importantly, myeloid cells such as macrophages can also adopt tolerogenic forms of IIM, known as Trained Tolerogenic Immunity (TTI). These observations suggest that strongest immunosuppressive myeloid-derived suppressor cells (MDSCs) could likewise be reprogrammed to develop TTI. Harnessing this phenotype through ACs presents a novel approach to adjuvant-based vaccine design. Therefore, building on the premise that ACs such as β-glucan induce robust TI in different innate cells, I hypothesize that selected ACs, or TLR agonists known to promote anti-inflammatory responses, can also elicit specific TTI in MDSCs, which could be leveraged for vaccine development against T cell–driven inflammatory diseases such as MS. To test this, I will characterise the functional, epigenetic and metabolic mechanisms of TTI induced by ACs in MDSCs, building on initial macrophage studies, for subsequently assessing their durability and immunosuppressive capacity using antigen-specific assays to, finally, evaluate their protective potential in a mouse model of MS. By identifying ACs capable of inducing TTI, this project aims to establish proof-of-concept for novel vaccines that optimise immune responses through precise balance of TI and TTI. These advances will not only contribute to improved vaccine strategies against inflammatory and infectious diseases but also serve as the foundation for my long-term career development in vaccinology.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology materials engineering amorphous solids amorphous semiconductors
- medical and health sciences health sciences infectious diseases
- medical and health sciences basic medicine neurology multiple sclerosis
- medical and health sciences basic medicine immunology
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-PF
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
48160 DERIO VIZCAYA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.