Objective
The apoplast is a critical battlefield where host immunity and microbial virulence collide. Plants rely on pattern recognition receptors (PRRs) and defense metabolites to sense and restrict microbial invasion, while pathogens evolve countermeasures to subvert these processes. Recent studies revealed that Pseudomonas syringae secretes glycosyrin, a unique iminosugar that promotes virulence by targeting the plant-secreted β-galactosidase BGAL1. BGAL1 is required for releasing the immunogenic flg22 epitope from glycosylated flagella, and glycosyrin blocks this process by inhibiting BGAL1. Beyond this specific role, emerging evidence implys that glycosyrin can broadly interfere with host glycobiology, potentially disrupting immune receptor maturation, blocking defense hormone release, and directly enhancing pathogen fitness.
This project aims to establish glycosyrin as a multi-faceted virulence factor that reprogrammes plant glycobiology to undermine immunity. Three objectives will be pursued: (1) reveal how glycosyrin deregulates immune receptor function through altered glycosylation and reduced receptor accumulation; (2) demonstrate how glycosyrin suppresses the release of salicylic acid from inactive conjugates, thereby dampening systemic immunity; and (3) determine how glycosyrin promotes osmoprotection by inducing the accumulation of apoplastic osmolytes that enhance pathogen survival under stress. These objectives will be addressed through a multidisciplinary strategy integrating receptor biology, proteomics, metabolomics, and functional infection assays. By revealing glycosyrin as a molecular weapon that hijacks glycosidase-dependent processes, this work will redefine how bacterial metabolites can manipulate host immunity. The results will deliver a step-change in our understanding of plant–pathogen interactions at the interface of glycobiology and immunity, while opening new avenues for engineering durable resistance in crops.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- agricultural sciences agriculture, forestry, and fisheries agriculture
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-PF
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
OX1 2JD Oxford
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.