Objective
Allenes are important to investigations in method development, drug discovery, and design of functional materials. While allenes are generated from alkynes, a method that makes it possible to convert alkenes, which are more abundant and less costly than alkyne, to allenes would be of considerable value. However, such methods are rare and those available require relatively forcing conditions and are not catalytic, limiting the applicability in complex molecule synthesis. Inspired by an unexpected recent discovery by the host group, we will develop a catalytic cross-coupling/elimination (CCE) method that will allow for efficient conversion of alkenes to 1,3-disubstituted allenes. The requisite substrates will be accessed either from olefins via cross-metathesis or from boronic acids/esters via cross-coupling. Cross-coupling will involve readily accessible alkenyl boronates are organohalides and cross-metathesis will be promoted by a Ru, or Mo catalysts, most originally developed by the host group. Our investigations will be guided by specific mechanistic attributes of CCE, as identified through preliminary DFT studies. The utility of catalytic CCE will be demonstrated in two ways: by efficient synthesis of bioactive allenes and through late-stage conversion of anti-cancer natural product epothilone C to its corresponding allenyl variants. These latter compounds highlight the fact that allenes represent a stable form of a twisted alkene (neither E or Z). We will show that through CCE uniquely shaped macrocyclic analogs can be obtained and utilized in lead discovery. The present investigations set the stage for eventual development of a catalytic enantioselective version of CCE.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-PF
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
67081 STRASBOURG
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.