Objective
Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) is a familial type of life-threatening arrhythmias which typically manifest with exercise or emotional stress. To date, most cases of CPVT have been linked to mutations in genes involved in Ca²⁺ regulation. Thus, shaping the current state of understanding CPVT as a Ca2+-driven arrhythmia. However, more than 30% of cases diagnosed with CPVT lack mutations in Ca2+-handling genes, indicating that other mechanisms may play a role. Recently, the host lab has identified a novel SCN5A variant, the gene encoding for the cardiac Na+ channels (NaV1.5 p.I1333V “IV”), in CPVT patients. Thus, raising the possibility that Na⁺ channelopathies may also contribute to stress-induced ventricular arrhythmias. Despite, there is currently no established framework for how such NaV1.5 variants might lead to the CPVT phenotype. Using state-of-the art electrophysiological and optical techniques, I will (O1) assess changes in channel kinetics and coupled gating using single-channel recordings, whereas using voltage-clamp fluorometry I will examine how the IV affects the channel’s voltage sensing apparatus; (O2) establish the cellular hallmarks of Na+-driven CPVT in human stem-cell-derived cardiomyocytes; and (O3) pharmacologically discriminate Na+-driven CPVT from the major arrhythmia caused by NaV1.5 gain of function, long QT type 3. By accomplishing the three objectives, I will provide a detailed molecular, cellular, and pharmacological understanding of Na+-driven CPVT, a potentially new type of familial, syncopal disease. Thus, providing enough evidence for SCN5A to be included in the CPVT screening pool, leading to improved diagnostic outcomes. In turn, this will reveal more CPVT-linked SCN5A variants and, most importantly, save lives. Ultimately, the MSCA fellowship will provide me with a diverse and multidisciplinary training towards the path to become an independent physician-scientist in cardiac electrophysiology.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
This project's classification has been human-validated.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
This project's classification has been human-validated.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-PF
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
581 83 Linkoping
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.