Project description
Improving studies on intrinsically disordered proteins
The study of intrinsically disordered proteins (IDPs), a functionally important class of proteins, is crucial to advancing a variety of processes, fields of research and industrial applications. Their study has proven complex, and the lack of standardised workflows has hindered data communication among researchers and the organisation of studies. Supported by the Marie Skłodowska-Curie Actions programme, the IDPexec project will collaborate with researchers in Europe, North America and Japan to study and develop an end-to-end, standards-first workflow for researching IDPs and for turning acquired data and evidence into trustworthy, functionally interpretable conformational ensembles. To achieve this, the project will focus on AI-assisted curation solutions, community standards, ontologies and multi-scale simulations.
Objective
IDPexec will transform how the community studies intrinsically disordered proteins (IDPs). IDPexec gathers leading groups in Europe, North America and Japan to deliver a standards-first, end-to-end workflow that turns heterogeneous evidence into trustworthy, functionally interpretable conformational ensembles. WP1 extends and operationalises community standards and ontologies, e.g. MIADE for experimental reporting, IDPO with GO/ECO for semantics. Curated records and ensembles will be deposited and cross-linked across databases (e.g. DisProt, PED, UniProt) to ensure FAIR access.
WP2 scales high-quality AI-assisted curation and adds evolutionary context (e.g. multiple sequence alignments, phylogenies and bulk feature) to prioritise conserved IDPs, identify lineage-specific segments and build gold-standard datasets. WP3 delivers integrative ensemble generation by combining multi-scale simulations with machine-learning guidance and rigorous refinement against NMR, EPR, SAXS/SANS and smFRET using Bayesian/maximum-entropy approaches with explicit uncertainty quantification. Open, containerised software and interoperable workflows will be released to the community.
WP4 establishes a benchmarking and validation framework with preregistered tasks, multi-criteria metrics (e.g. fit to observables, uncertainty) and public leaderboards—closing the loop between method development and biological insight (e.g. phase separation, transient secondary structure, mutation sensitivity). International secondments drive bidirectional knowledge transfer among curators, experimentalists and modellers. Training events build a skilled workforce fluent in standards, FAIR data stewardship and integrative modelling. By delivering calibrated forward models and uncertainty-aware refinement, and institutionalising open benchmarks, IDPexec will raise the bar for IDP research, accelerate adoption in academia and industry, and position Europe as a global hub for IDP data, methods and training.
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Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
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(opens in new window) HORIZON-MSCA-2025-SE-01
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35122 Padova
Italy
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Participants (6)
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75794 Paris
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1053 Budapest
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75724 Paris
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1165 KOBENHAVN
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1206 Genf
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CB2 1TN CAMBRIDGE
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Partners (11)
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03755 HANOVER
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90089 5013 Los Angeles Ca
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MO 63130-4899 St Louis
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Memphis
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M5S 1A1 Toronto
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464 8601 Nagoya
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371-0816 Maebashi
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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75654 Paris
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31400 Toulouse
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31077 Toulouse
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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75230 Paris
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