Objective
Tissues must coordinate multicellular actions with stimuli to function and to respond to their environment. The gain of tissue coordination is associated with development and the converse is true for disease. To study tissue coordination and responses, it would be powerful to directly image how information flows from stimuli, through patterns of cell states, to tissue responses. However, the complexity of animal tissues has made it difficult to interrogate all these levels of information-processing.
To develop principles by which tissue process information, I will use Dictyostelium, a soil-dwelling amoeba that forms a multicellular “slug” that navigates the soil by processing various stimuli, such as light and temperature, to inform migratory decisions. With this self-organising system of manageable complexity, I will determine how tissue responses are generated by signalling patterns whose structure a) adapts to stimuli and b) organises cell motion. This information-processing mechanism will be tested by 3D live imaging, quantifying and perturbing how tissue development is self-organised through signalling pattern formation, and how tissue function is organised by signalling pattern adaptation. The outcome will be a mechanistic map of information flow in which a tissue forms a perception of its environment and then adapts a signalling pattern which encodes and coordinates tissue responses. This research programme will establish how complex tissue responses and information-processing emerge from generic cell behaviours.
Fields of science (EuroSciVoc)
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2026-STG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
OX1 2JD Oxford
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.