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3D imaging of information processing in live tissues

Obiettivo

Tissues must coordinate multicellular actions with stimuli to function and to respond to their environment. The gain of tissue coordination is associated with development and the converse is true for disease. To study tissue coordination and responses, it would be powerful to directly image how information flows from stimuli, through patterns of cell states, to tissue responses. However, the complexity of animal tissues has made it difficult to interrogate all these levels of information-processing.

To develop principles by which tissue process information, I will use Dictyostelium, a soil-dwelling amoeba that forms a multicellular “slug” that navigates the soil by processing various stimuli, such as light and temperature, to inform migratory decisions. With this self-organising system of manageable complexity, I will determine how tissue responses are generated by signalling patterns whose structure a) adapts to stimuli and b) organises cell motion. This information-processing mechanism will be tested by 3D live imaging, quantifying and perturbing how tissue development is self-organised through signalling pattern formation, and how tissue function is organised by signalling pattern adaptation. The outcome will be a mechanistic map of information flow in which a tissue forms a perception of its environment and then adapts a signalling pattern which encodes and coordinates tissue responses. This research programme will establish how complex tissue responses and information-processing emerge from generic cell behaviours.

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HORIZON-ERC - HORIZON ERC Grants

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Istituzione ospitante

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Contributo netto dell'UE
€ 1 600 833,00
Indirizzo
WELLINGTON SQUARE UNIVERSITY OFFICES
OX1 2JD Oxford
Regno Unito
Regione
South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire
Tipo di attività
Higher or Secondary Education Establishments
Collegamenti
Costo totale
€ 1 600 833,00

Beneficiari (1)