Objective
Coherent Raman imaging can provide rapid, label-free virtual histology, but its clinical translation is constrained by detection geometry and detector noise. Standard stimulated Raman scattering relies on forward detection, which is poorly suited to thick, highly scattering tissue and therefore limits intraoperative implementations. In our ERC-funded research, we introduced backscattering coherent Stokes Raman scattering (b-CSRS), a coherent Raman modality whose red-shifted emission enables epi detection and is compatible with laser scanning and spectrally resolved acquisition. However, current b-CSRS detection is limited by detector noise, preventing shot-noise-limited, high-speed imaging and spectroscopy.
This Proof-of-Concept will remove that bottleneck by developing a compact, low-noise amplified readout strategy for b-CSRS, enabling improved sensitivity, speed, and spectral fidelity in detector-friendly operating regimes. The project will deliver an alignment-robust readout module compatible with laser-scanning microscopes, quantitative benchmarks against current direct detection approaches, and a validated route toward parallel, multi-channel spectroscopic b-CSRS for tissue classification. Together, these advances will transform b-CSRS from a promising laboratory method into a scalable platform for real-time molecular tissue assessment.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine oncology
- natural sciences mathematics pure mathematics geometry
- natural sciences biological sciences histology
- natural sciences physical sciences optics laser physics
- natural sciences physical sciences optics spectroscopy
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC-POC - HORIZON ERC Proof of Concept Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2026-POC
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75794 Paris
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.