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Multiscale 3D virtual histology with non-destructive x-rays

Objetivo

XHIST aims to introduce three-dimensional virtual histology into clinical pathology using non-destructive X-ray phase-contrast tomography. Conventional histopathology relies on micrometre-thin slices cut from standardized formalin-fixed paraffin-embedded (FFPE) tissue blocks. By slicing, routinely only about 1% of the tissue in these millimeter-thick blocks is assessed and the three-dimensional organisation can only be extrapolated. XHIST mitigates these constraints by enabling volumetric imaging of entire FFPE tissue blocks with sub-micron voxel size, spatial resolution comparable to conventional histopathology, but without staining or destructive preparation and all within a time frame of two hours.
The technology builds on advances from ERC-funded research in multiscale X-ray imaging. A newly developed 150-megapixel detector, combined with high-brightness X-ray sources and phase-contrast reconstruction methods, enables simultaneous large field-of-view imaging and high spatial resolution, allowing cellular structures to be visualised across entire tissue volumes.
The objective of this Proof-of-Concept project is to translate this technology toward clinical use by developing a prototype scanner, automated acquisition and reconstruction workflows, and visualisation tools that integrate with existing pathology practice. The system will be validated in the clinical cases; (i) tumour margin assessment and (ii) detection of microvascular invasion in liver cancer.
The project will also develop an intellectual property and commercialization strategy aimed at translating XHIST into a deployable stand-alone imaging platform for hospital pathology laboratories, the primary market for the technology, and laying the foundation for a future start-up commercializing the system.

Ámbito científico (EuroSciVoc)

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Programa(s)

Tema(s)

Régimen de financiación

HORIZON-ERC-POC - HORIZON ERC Proof of Concept Grants

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Convocatoria de propuestas

(se abrirá en una nueva ventana) ERC-2026-POC

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Institución de acogida

DANMARKS TEKNISKE UNIVERSITET
Aportación neta de la UEn
€ 150 000,00
Dirección
ANKER ENGELUNDS VEJ 101
2800 Kongens Lyngby
Dinamarca
Región
Danmark Hovedstaden Københavns omegn
Tipo de actividad
Higher or Secondary Education Establishments
Enlaces
Coste total
Sin datos

Beneficiarios (1)