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Next-generation biomimetic vesicles for combating antimicrobial resistance in chronic biofilm infections

Objectif

ARMOR addresses a major challenge in modern medicine: chronic biofilm-associated infections, which are highly resistant to antibiotics and closely linked to antimicrobial resistance. The project will develop a new generation of safe, biomimetic nanovesicles inspired by bacterial outer membrane vesicles that can penetrate biofilms and deliver therapeutics directly to the infection site. By combining detoxified bacterial membrane components with synthetic lipids and responsive materials, ARMOR aims to create programmable vesicles that release their cargo only under biofilm-specific conditions such as acidic pH or bacterial enzymes. The platform will integrate multiple antimicrobial strategies, including antibiotics, antimicrobial peptides, enzymes, and light- and ultrasound-activated agents, to achieve targeted and synergistic biofilm eradication. A distinctive feature of ARMOR is its closed design-build-test-learn framework, in which artificial intelligence, advanced imaging, and quantitative in vitro and in vivo data are combined to iteratively optimise vesicle design, delivery, efficacy, and safety. The project brings together an international, interdisciplinary, and intersectoral consortium spanning academia and industry across Europe and beyond. Through structured staff secondments, shared training, and joint research activities, ARMOR will promote deep transfer of knowledge and build durable collaboration networks. ARMOR is expected to deliver validated preclinical lead formulations, AI-enabled optimisation workflows, and scalable approaches for vesicle production, stabilisation, and quality control. In the longer term, the project will strengthen Europe’s capacity to develop precision anti-infective therapies, reduce reliance on conventional antibiotics, and improve the management of chronic biofilm infections and antimicrobial resistance.

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Mots‑clés

Programme(s)

Thème(s)

Régime de financement

HORIZON-TMA-MSCA-SE - HORIZON TMA MSCA Staff Exchanges

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Appel à propositions

(s’ouvre dans une nouvelle fenêtre) HORIZON-MSCA-2026-SE-01

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Coordinateur

UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA
Contribution nette de l'UE
€ 320 540,00
Coût total
Aucune donnée

Participants (8)

Partenaires (5)